VETPROFEN- carprofen tablet, coated

Land: USA

Språk: engelsk

Kilde: NLM (National Library of Medicine)

Aktiv ingrediens:

Carprofen (UNII: FFL0D546HO) (Carprofen - UNII:FFL0D546HO)

Tilgjengelig fra:

Vetoquinol USA, Inc.

INN (International Name):

Carprofen

Sammensetning:

Carprofen 25 mg

Administreringsrute:

ORAL

Resept typen:

PRESCRIPTION

Indikasjoner:

INDICATIONS: Vetprofen Flavored Tab is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. CONTRAINDICATIONS: Vetprofen Flavored Tab should not be used in dogs exhibiting previous hypersensitivity to carprofen.

Produkt oppsummering:

HOW SUPPLIED: Vetprofen Flavored Tab are scored, and contain 25 mg, 75 mg, or 100 mg of carprofen per tablet. Each tablet size is packaged in bottles containing 30, 60, or 180 tablets.

Autorisasjon status:

Abbreviated New Animal Drug Application

Preparatomtale

VETPROFEN- CARPROFEN TABLET, COATED
VETOQUINOL USA, INC.
----------
VETPROFEN FLAVORED TAB
(CARPROFEN FLAVORED TABLETS)
_NON-STEROIDAL ANTI-INFLAMMATORY DRUG_
FOR ORAL USE IN DOGS ONLY
CAUTION: Federal law restricts this drug to use by or on the order of
a licensed veterinarian.
DESCRIPTION: Vetprofen Flavored Tab is a non-steroidal
anti-inflammatory drug (NSAID) of the
propionic acid class that includes ibuprofen, naproxen, and
ketoprofen. Vetprofen Flavored Tab is the
nonproprietary designation for a substituted carbazole,
6-chloro-α-methyl-9H-carbazole-2-acetic acid.
The empirical formula is C
H ClNO and the molecular weight 273.72. The chemical structure of
carprofen is:
Carprofen is a white, crystalline compound. It is freely soluble in
ethanol, but practically insoluble in
water at 25°C.
CLINICAL PHARMACOLOGY: Carprofen is a non-narcotic, non-steroidal
anti-inflammatory agent
with characteristic analgesic and antipyretic activity approximately
equipotent to indomethacin in animal
models.
The mechanism of action of carprofen, like that of other NSAIDs, is
believed to be associated with the
inhibition of cyclooxygenase activity. Two unique cyclooxygenases have
been described in mammals.
The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins
necessary for normal
gastrointestinal and renal function. The inducible cyclooxygenase,
COX-2, generates prostaglandins
involved in inflammation.
Inhibition of COX-1 is thought to be associated with gastrointestinal
and renal toxicity while inhibition
of COX-2 provides anti-inflammatory activity. The specificity of a
particular NSAID for COX-2
versus COX-1 may vary from species to species.
In an in vitro study using canine cell cultures,
carprofen demonstrated selective inhibition of COX-2 versus COX-1.
Clinical relevance of these data
has not been shown.
Carprofen has also been shown to inhibit the release of several
prostaglandins in two inflammatory cell
systems: rat polymorphonuclear leukocytes (PMN) and human rheumatoid
synovial cells, indicating
inhibit