Trusopt

Land: Australia

Språk: engelsk

Kilde: Department of Health (Therapeutic Goods Administration)

Aktiv ingrediens:

Dorzolamide hydrochloride

Tilgjengelig fra:

Merck Sharp & Dohme Australia Pty Ltd

Klasse:

Medicine Listed (Export Only)

Informasjon til brukeren

TRUSOPT
®

_Dorzolamide hydrochloride_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about TRUSOPT. It does
not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using TRUSOPT
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
USING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT TRUSOPT IS
USED FOR
TRUSOPT is used to lower raised
pressure in the eye and to treat
glaucoma. Glaucoma is a condition
in which the pressure of fluid in the
eye may be high. However, some
people with glaucoma may have
normal eye pressure. Also, some
people with raised eye pressure may
not have glaucoma.
Glaucoma is caused by a build-up of
the fluid which flows through the
eye. This build-up occurs because the
fluid drains out of your eye more
slowly than it is being pumped in.
Since new fluid continues to enter the
eye, joining the fluid already there,
the pressure continues to rise. This
raised pressure may damage the back
of the eye resulting in gradual loss of
sight. Damage can progress so slowly
that the person is not aware of this
gradual loss of sight.
Sometimes even normal eye pressure
is associated with damage to the back
of the eye.
There are usually no symptoms of
glaucoma. The only way of knowing
that you have glaucoma is to have
your eye pressure, optic nerve and
visual field checked by an eye
specialist or optometrist. If glaucoma
is not treated it can lead to serious
problems. You may have no
symptoms but eventually glaucoma
can lead to total blindness. In fact,
untreated glaucoma is one of the
most common causes of blindness.
Although TRUSOPT helps control
your glaucoma it does not cure it.
For more information about
glaucoma, contact Glaucoma
Australia Inc., PO Box 420, Crows
Nest 1585, telephone [phone].
TRUSOPT

Preparatomtale

WPC–MK0507-OS-122009s

1
PRODUCT INFORMATION 

TRUSOPT
®
 EYE DROPS, 20MG/ML 

(DORZOLAMIDE HYDROCHLORIDE EYE DROPS MSD) 

THERAPEUTIC CLASS 

TRUSOPT
® (dorzolamide hydrochloride eye drops, MSD) is a novel carbonic 
anhydrase inhibitor formulated for topical ophthalmic use.  Unlike
oral carbonic 
anhydrase inhibitors, TRUSOPT, which is administered topically,
exerts its effects 
directly in the eye. 

CHEMISTRY 

TRUSOPT Eye Drops contain dorzolamide hydrochloride, which is
described 
chemically as: (4_S_,
6_S_)-4-ethylamino-5,6-dihydro-6-methyl-4_H_-thieno[2,3-_b_]thiopyran-
2-sulfonamide 7,7-dioxide monohydrochloride.  Dorzolamide
hydrochloride is 
optically active.   
The specific rotation is 
α25°    (C=1, water) = ~ -17°. 

             405 

Dorzolamide hydrochloride Chemical Abstract Registry number -
130693-82-2. 

Its empirical formula is C10H17N2O4S3Cl and its structural formula
is: 

_ _

Dorzolamide hydrochloride has a molecular weight of 360.9 and
a melting point of 
about 275
°C.  It is a white to off-white, free
flowing crystalline powder, which is 
soluble in water and slightly soluble in methanol and ethanol. 

CLINICAL PHARMACOLOGY 

Carbonic anhydrase (CA) is an enzyme found in many tissues
of the body including 
the eye.  It catalyzes the reversible reaction involving the
hydration of carbon dioxide 
and the dehydration of carbonic acid.  In humans, carbonic anhydrase
exists as a 
number of isoenzymes, the most active being carbonic anhydrase II
(CA-II) found 
primarily in red blood cells (RBCs) but also in other tissues.
 Inhibition of  carbonic 
anhydrase in the ciliary processes of the eye decreases aqueous
humor secretion, 

®
 Registered Trademark of Merck Sharp & Dohme Corp., a subsidiary of
Merck & CO., Inc. 
Whitehouse Station, N.J., U.S.A. 
WPC–MK0507-OS-122