TRIAMCINOLONE ACETONIDE ointment

Land: USA

Språk: engelsk

Kilde: NLM (National Library of Medicine)

Aktiv ingrediens:

Triamcinolone Acetonide (UNII: F446C597KA) (Triamcinolone - UNII:1ZK20VI6TY)

Tilgjengelig fra:

Rebel Distributors Corp

INN (International Name):

Triamcinolone Acetonide

Sammensetning:

Triamcinolone Acetonide 0.25 mg in 1 g

Administreringsrute:

TOPICAL

Resept typen:

PRESCRIPTION DRUG

Indikasjoner:

Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.

Produkt oppsummering:

Triamcinolone Acetonide Ointment USP, 0.025% 80 gram tubes   NDC 21695-503-80   Triamcinolone Acetonide Ointment USP, 0.1% 15 gram tubes   NDC 21695-504-15 80 gram tubes   NDC 21695-504-80 Store at controlled room temperature 15°-30°C (59°-86°F). March 2008 E. FOUGERA & CO. A division of Nycomed US Inc. MELVILLE, NEW YORK 11747 Repackaged by: REBEL DISTRIBUTORS CORP Thousand Oaks, CA 91320

Autorisasjon status:

Abbreviated New Drug Application

Preparatomtale

TRIAMCINOLONE ACETONIDE- TRIAMCINOLONE ACETONIDE OINTMENT
REBEL DISTRIBUTORS CORP
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TRIAMCINOLONE ACETONIDE OINTMENT USP, 0.025%, 0.1%
RX ONLY
DESCRIPTION
The topical corticosteroids constitute a class of primarily synthetic
steroids used as anti-inflammatory
and anti-pruritic agents. Triamcinolone Acetonide Ointment USP
contains Triamcinolone Acetonide
[Pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis-(oxy)]-,
(11β,16α)-], with the molecular formula C
H FO and molecular weight 434.50. CAS 76-25-5.
Triamcinolone Acetonide Ointment USP, 0.025% contains: 0.25 mg of
triamcinolone acetonide per gram
in a base containing white petrolatum and mineral oil.
Triamcinolone Acetonide Ointment USP, 0.1% contains: 1 mg
triamcinolone acetonide per gram in a
base containing white petrolatum and mineral oil.
CLINICAL PHARMACOLOGY
Topical corticosteroids share anti-inflammatory, anti-pruritic and
vasoconstrictive actions. The
mechanism of anti-inflammatory activity of the topical corticosteroids
is unclear. Various laboratory
methods, including vasoconstrictor assays, are used to compare and
predict potencies and/or clinical
efficacies of the topical corticosteroids. There is some evidence to
suggest that a recognizable
correlation exists between vasoconstrictor potency and therapeutic
efficacy in man.
PHARMACOKINETICS: The extent of percutaneous absorption of topical
corticosteroids is determined by
many factors including the vehicle, the integrity of the epidermal
barrier, and the use of occlusive
dressings. Topical corticosteroids can be absorbed from normal intact
skin. Inflammation and/or other
disease processes in the skin increase percutaneous absorption.
Occlusive dressings substantially
increase the percutaneous absorption of topical corticosteroids. Thus,
occlusive dressings may be a
valuable therapeutic adjunct for treatment of resistant dermatoses
(See DOSAGE AND
ADMINISTRATION). Once absorbed through the skin, topical
corticosteroids are handled through
pharmacokinetic pa