Sinemet Tablet 25/250 mg

Land: Malaysia

Språk: engelsk

Kilde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktiv ingrediens:

CARBIDOPA; LEVODOPA

Tilgjengelig fra:

MERCK SHARP & DOHME (MALAYSIA) SDN BHD

INN (International Name):

CARBIDOPA; LEVODOPA

Enheter i pakken:

100tablet Tablets

Produsert av:

Mylan Pharmaceuticals Inc.

Informasjon til brukeren

_Consumer Medication Information Leaflet (RiMUP) _
SINEMET
® TABLET
Carbidopa/Levodopa (25/100mg, 25/250 mg)
______________________________________________________________________________________________________
1
WHAT IS IN THIS LEAFLET
1.
What SINEMET is used for
2.
How SINEMET works
3.
Before you use SINEMET
4.
How to use SINEMET
5.
While you are using SINEMET
6.
Side effects
7.
Storage and Disposal of
SINEMET
8.
Product description
9.
Product Manufacturer and
Product Registration Holder
10.
Date of Revision
WHAT SINEMET IS USED FOR
SINEMET is a combination of
carbidopa, an aromatic amino
acid decarboxylase inhibitor, and
levodopa, the metabolic precursor
of dopamine. It improves the
symptoms of Parkinson's disease.
WHY HAS MY DOCTOR PRESCRIBED
SINEMET?
Your doctor has prescribed
SINEMET to treat the symptoms of
Parkinson's disease.
Parkinson's disease is a chronic
disorder characterized by slow
and unsteady movement,
muscular stiffness, and tremor.
If untreated, Parkinson's disease
can cause difficulty in
performing normal daily
activities.
HOW SINEMET WORKS
SINEMET tablets contain two
active ingredients, levodopa and
carbidopa.
It is believed that the symptoms
of Parkinson's Disease are caused
by a lack of dopamine, a
naturally occurring chemical
produced by certain brain cells.
Dopamine has the role of
relaying messages in certain
regions of the brain that control
muscle movement. Difficulty in
movement results when too little
dopamine is produced.
Levodopa acts to replenish
dopamine in the brain, while
carbidopa ensures that enough
levodopa gets to the brain where
it is needed. In many patients,
this reduces the symptoms of
Parkinson's disease.
BEFORE YOU USE SINEMET
-
_When you must not use it _
Do not take SINEMET if you:
•
are allergic to any of its
ingredients
•
have any suspicious skin
lesions (moles) which have
not been examined by your
doctor or if you have ever
had skin cancer
•
are being treated for depression
with certain MAO inhibitor
drugs
•
have narrow-angle glaucoma
_- Before you sta

Preparatomtale

LPC -MK0295B -T-082013 a
LOCAL PRODUCT CIRCULAR
SINEMET ®
(carbidopa and levodopa, MSD)
CLINICAL PHARMACOLOGY
Mechanism of Action
SINEMET ® is a combination of carbidopa, an aromatic amino acid decarboxylase
inhibitor, and levodopa, the metabolic pre cursor of dopamine, for use in the treatment of
Parkinson's disease and syndrome.
Levodopa relieves the symptoms of Parkinson's disease by being decarboxyl ated to
dopamine in the brain. Carbidopa, which does not cross the blood -brain barrier, inhibits
the extracerebral decarboxylation of levodopa, making more levodopa available for
transport to the brain and subs equent conversion to dopamine.
SINEMET improves overall therapeutic res ponse as compared to levodopa. SINEMET
provides effective long -lasting l evodopa plasma levels at doses that are approximately
80 percent lower than those needed with levodopa alone.
While pyridoxine hydrochloride (Vitamin B 6) is known to accelerate the peripheral
metabolism of levodopa to dopamine, carbidopa prevents this act ion.
ONSET OF ACTION WITH USUAL DOSES