Land: Malaysia
Språk: engelsk
Kilde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ROBENIDINE HYDROCHLORIDE
RANGE PHARMA SDN. BHD.
ROBENIDINE HYDROCHLORIDE
25 kg; 10 kg
RANGE PHARMA SDN. BHD.
ROBENXIN 66G/KG POWDER DESCRIPTION AND COMPOSITION ROBENXIN 66G/KG POWDER is an off white to yellowish powder. Each kg contains 66g of Robenidine Hydrochloride as its active ingredient. PHARMACODYNAMICS Antiprotozoal containing robenidine hydrochloride is used for anticoccidial treatment in broiler production. Shows anticoccidial activities against: _Eimeria acervulina_, _E. maxima_, _E. tenella_, _E. necatrix_, _E. brunetti_ and _E. mivati_. Acting robenidine hydrochloride is the result of dual action which is shown at different stages of the parasite's development in the intestinal mucosal part of broiler chickens. The first mechanism of action is reflected like this: robenidine hydrochloride inhibits the development of the first generation schizont, and the other is reflected by killing another generation schizont and possibly merozoite. Also, robenidine hydrochloride acts on gametogenesis parasites. Dual mechanism of action is particularly advantageous for anticoccidial drugs, because the risk of relapse is reduced in case of bird's stress and following feed termination. Combination of coccidiocides and coccidiostatic effects is also important factor in minimizing the possibility of clinical manifestation of coccidiosis after the discontinuation of robenidine hydrochloride. By using histochemical techniques, it has been confirmed that robenidine hydrochloride has a negative effect on the development of the first generation of schizont, first generation of merozoite and the second generation of schizont. It was also confirmed that robenidine hydrochloride gives effect in preventing anticoccidial protein synthesis. PHARMACOKINETICS Reabsorption After oral application, robenidine is partially absorbed from the gastrointestinal tract (20 to 40%) and rapidly excreted, mainly it is not metabolized. Distribution After a single dose (5 to 8 times higher than the recommended dose), robenidine distribution in tissues and the medicine reaches the highest concentration for 8 hours in the muscles, liver, kidneys and blood Les hele dokumentet