Probenecid-AFT

Land: New Zealand

Språk: engelsk

Kilde: Medsafe (Medicines Safety Authority)

Aktiv ingrediens:

Probenecid 500mg;  ;  ;  ;  ; Probenecid 500mg; Probenecid 500mg

Tilgjengelig fra:

AFT Pharmaceuticals Ltd

INN (International Name):

Probenecid 500 mg

Dosering :

500 mg

Legemiddelform:

Film coated tablet

Sammensetning:

Active: Probenecid 500mg         Excipient: Colloidal silicon dioxide Magnesium stearate Maize starch Microcrystalline cellulose Opadry clear YS-1-7006 Opadry yellow YS-1-2063 Povidone Sodium starch glycolate Stearic acid Active: Probenecid 500mg Excipient: Colloidal silicon dioxide Magnesium stearate Maize starch Microcrystalline cellulose Opadry clear YS-1-7006 Opadry yellow YS-1-2063 Povidone Sodium starch glycolate Stearic acid Active: Probenecid 500mg Excipient: Colloidal silicon dioxide Magnesium stearate Maize starch Microcrystalline cellulose Opadry clear YS-1-7006 Opadry yellow YS-1-2063 Povidone Sodium starch glycolate Stearic acid

Enheter i pakken:

Bottle, HDPE with HDPE cap, 100 tablets

Klasse:

Prescription

Resept typen:

Prescription

Produsert av:

Plantex Ltd

Indikasjoner:

· Probenecid is a uricosuric agent for the treatment of hyperuricaemia in all stages of gout and gouty arthritis except a presenting acute attack. Asymptomatic hyperuricaemia seems to occur in a significant percentage of relatives of gouty patients. Probenecid may be given prophylactically to these people to forestall gouty attacks and urate deposition in tissues. By virtue of its effective uricosuric activity, probenecid may be used to control the hyperuricaemia induced or aggravated by many diuretics employed for the treatment of oedema and hypertension (e.g. thiazides and similar diuretics).

Produkt oppsummering:

Package - Contents - Shelf Life: Bottle, HDPE with HDPE cap - 100 tablets - 48 months from date of manufacture stored at or below 30°C

Autorisasjon dato:

2008-05-01

Preparatomtale

Page 1 of 8
NEW ZEALAND DATA SHEET
1. PROBENECID-AFT, PROBENECID 500 MG FILM COATED TABLETS
PROBENECID-AFT, Probenecid 500 mg film coated tablets
2 QUALITATIVE AND QUANTITATIVE COMPOSITION
Each tablet contains 500 mg Probenecid
For full list of excipients, see section 6.1
3 PHARMACEUTICAL FORM
Probenecid-AFT tablets are yellow capsule-shaped, film coated tablets,
bisected on one side
and plain on the other.
4 CLINICAL PARTICULARS
4.1
THERAPEUTIC INDICATIONS
GOUT
Probenecid is a uricosuric agent for the treatment of hyperuricaemia
in all stages of gout
and gouty arthritis except a presenting acute attack.
Asymptomatic hyperuricaemia seems to occur in a significant percentage
of relatives of
gouty patients. Probenecid may be given prophylactically to these
people to forestall
gouty attacks and urate deposition in tissues. By virtue of its
effective uricosuric activity,
probenecid may be used to control the hyperuricaemia induced or
aggravated by many
diuretics employed for the treatment of
oedema and hypertension (e.g. thiazides and
similar diuretics).
B-LACTAM ANTIBIOTIC THERAPY
Probenecid is indicated for the elevation and prolongation of plasma
levels by whatever
route the antibiotic is given. A two-to-fourfold increase in plasma
levels has been
demonstrated for penicillin G or V, the synthetic penicillins,
ampicillin, methicillin, oxacillin,
cloxacillin, nafcillin,
carbenicillin, and for the cephamycin, cefoxitin sodium, and the
cephalosporins, cephalothin,
cephalexin and cephaloglycin.
Page 2 of 8
4.2
DOSE AND METHOD OF ADMINISTRATION
GOUT
Probenecid therapy should not be initiated until an acute gouty attack
has subsided.
Should an acute attack be precipitated during therapy, the drug may be
continued without
changing
the dosage, and therapeutic doses of colchicine, indomethacin, or
other
appropriate therapy may be administered to control the acute attack.
ADULT
The recommended dose for adults is 250 mg (½ tablet) twice a day for
one week, followed
by 500 mg (1 tablet) twice a day thereafter.
As some degree