PENICILLIN V POTASIUM tablet

Land: USA

Språk: engelsk

Kilde: NLM (National Library of Medicine)

Aktiv ingrediens:

PENICILLIN V POTASSIUM (UNII: 146T0TU1JB) (PENICILLIN V - UNII:Z61I075U2W)

Tilgjengelig fra:

Avera McKennan Hospital

INN (International Name):

PENICILLIN V POTASSIUM

Sammensetning:

PENICILLIN V 250 mg

Resept typen:

PRESCRIPTION DRUG

Autorisasjon status:

Abbreviated New Drug Application

Preparatomtale

PENICILLIN V POTASIUM- PENICILLIN V POTASIUM TABLET
AVERA MCKENNAN HOSPITAL
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PENICILLIN-VK
PENICILLIN V POTASSIUM TABLETS, USP
250 MG (400,000 UNITS)
500 MG (800,000 UNITS)
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of penicillin-VK
and other antibacterial drugs, penicillin-VK should be used only to
treat or prevent infections that are
proven or strongly suspected to be caused by bacteria.
DESCRIPTION
Penicillin V is the phenoxymethyl analog of penicillin G.
Penicillin V potassium is the potassium salt of penicillin V.
Molecular Formula: C
H O KN S Molecular Weight: 388.5
Penicillin -VK (Penicillin V Potassium Tablets USP), for oral
administration, contain 250 mg (400,000
units) or 500 mg (800,000 units) penicillin V. In addition, each
tablet contains the following inactive
ingredients: hydroxypropyl methylcellulose, magnesium stearate,
polyethylene glycol, povidone, talc,
and titanium dioxide.
CLINICAL PHARMACOLOGY
Penicillin V exerts a bactericidal action against penicillin-sensitive
microorganisms during the stage of
active multiplication. It acts through the inhibition of biosynthesis
of cell-wall mucopeptide. It is not
active against the penicillinase-producing bacteria, which include
many strains of staphylococci. The
drug exerts high _in vitro_ activity against staphylococci (except
penicillinase-producing strains),
streptococci (groups A, C, G, H, L and M), and pneumococci. Other
organisms sensitive _in vitro_ to
penicillin V are _Corynebacteriumdiphtheriae, Bacillus anthracis,
Clostridia, Actinomycesbovis,_
_Streptobacillusmoniliformis, Listeria monocytogenes, Leptospira, and
Neisseria gonorrhoeae._
_Treponemapallidum_ is extremely sensitive.
The potassium salt of penicillin V has the distinct advantage over
penicillin G in resistance to
inactivation by gastric acid. It may be given with meals; however,
blood levels are slightly higher when
the drug is given on an empty stomach. Average blood levels are two to
five times higher than the
levels following