METOCLOPRAMIDE AN metoclopramide hydrochloride 10 mg film coated tablets blister pack

Land: Australia

Språk: engelsk

Kilde: Department of Health (Therapeutic Goods Administration)

Aktiv ingrediens:

metoclopramide hydrochloride

Tilgjengelig fra:

Amneal Pharma Australia Pty Ltd

INN (International Name):

metoclopramide hydrochloride

Autorisasjon status:

Registered

Informasjon til brukeren

METOCLOPRAMIDE AN CMI v1.
Page 1 of 7
METOCLOPRAMIDE AN
_Metoclopramide hydrochloride _
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common questions about Metoclopramide AN. It
does not contain
all the available information. It does not take the place of talking
to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the
risks of you taking
Metoclopramide AN against the benefits they expect it will have for
you.
IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR
OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again.
WHAT METOCLOPRAMIDE AN IS USED FOR
In adults over 20 years this medicine is used to:

treat nausea and vomiting caused by infectious diseases, kidney
disease, child birth, other
medications, cancer, or following surgery, chemotherapy or radiation
treatment.

activate stomach contractions in conditions where there is a need to
encourage normal
passage of food through the stomach and intestines.

with X-rays to help diagnose problems of the stomach and/or
intestines.

help with passing tubes into the intestine.
In young adults between 15 to 20 years this medicines is used to:

treat severe vomiting of known cause or following chemotherapy or
radiation treatment.

help with passing tubes into the intestine.
These tablets should not be used for children under 15 years of age.
This medicine works by blocking the action of a chemical in the brain
which causes nausea
and vomiting. It also acts in the stomach and upper intestine to
increase muscle contractions
ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE HAS
BEEN
PRESCRIBED FOR YOU OR YOUR CHILD.
Your doctor may have prescribed it for another reason.
BEFORE YOU OR YOUR CHILD TAKE METOCLOPRAMIDE AN
_ _
_WHEN YOU OR YOUR CHILD MUST NOT TAKE IT _
DO NOT TAKE METOCLOPRAMIDE AN IF YOU OR YOUR CHILD HAVE AN ALLERGY TO:

any medicine containing Metoclopramide

any of the ingredients listed at the end of t

Preparatomtale

_Metoclopramide AN tablets Product Information _
_ _
_ Amneal Pharma Australia Pty Ltd _
METOCLOPRAMIDE AN
_ _
_(METOCHLOPRAMIDE HYDROCHLORIDE TABLETS) _
PRODUCT INFORMATION
NAME OF THE MEDICINE
The name of this medicine is metoclopramide hydrochloride
CHEMICAL NAME:
N-(diethyl-aminoethyl)-2-methoxy-4-amino-5-chlorbenzamide
monohydrochloride monohydrate.
MOLECULAR FORMULA:
C
14
H
22
ClN
3
O
2
, HCl, H
2
0
MOLECULAR WEIGHT:
354.3
CAS NUMBER:
54143 – 57 - 6
DESCRIPTION
Metoclopramide hydrochloride occurs as a white or almost white,
crystalline powder or
crystals, very soluble in water, freely soluble in alcohol, sparingly
soluble in methylene
chloride, practically insoluble in ether.
Metoclopramide AN tablets also contain the excipients microcrystalline
cellulose, colloidal
anhydrous silica, maize starch, stearic acid and pregelatinised maize
starch. The coating for the
tablets consists of hypromellose, macrogol 6000, titanium dioxide and
purified talc.
PHARMACOLOGY
Metoclopramide hydrochloride stimulates motility of the upper
gastrointestinal tract without
stimulating gastric, biliary, or pancreatic secretions. Its mode of
action is unclear. It seems to
sensitise tissues to the action of acetylcholine. The effect of
metoclopramide hydrochloride on
motility is not dependent on intact vagal innervation, but it can be
abolished by anticholinergic
drugs.
Metoclopramide hydrochloride increases the tone and amplitude of
gastric (especially antral)
contractions, relaxes the pyloric sphincter and the duodenal bulb, and
increases peristalsis of
the duodenum and jejunum resulting in accelerated gastric emptying and
intestinal transit. It
increases the resting tone of the lower oesophageal sphincter. It has
little, if any effect on the
motility of the colon or gall bladder.
Metoclopramide hydrochloride has dopamine antagonist activity. Like
the phenothiazines and
related drugs, which are also dopamine antagonists, metoclopramide
hydrochloride produces
sedation and may produce extra-pyramidal reactions (see
PRECAUTIONS
). M