Land: Indonesia
Språk: indonesisk
Kilde: Badan Pengawas Obat dan Makanan RI - Indonesian Food and Drug Supervisory Agency
IVERMECTIN
HARSEN - Indonesia
IVERMECTIN
12 Mg
KAPLET
DUS, 1 STRIP @ 10 KAPLET
HARSEN - Indonesia
2021-04-05
IVERMAX 12 IVERMECTIN Caplet 12 mg Following oral administration of Ivermax, plasma concentrations are approximately proportional to the dose. Ivermax is metabolized in the liver, and Ivermax and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1% of the administered dose excreted in the urine. The plasma half-life of Ivermax in man is approximately 18 hours following oral administration. I V E R M A X s h o u l d b e t a k e n o n a n e m p t y s t o m a c h w i t h w a t e r. ( S e e CLINICAL PHARMACOLOGY, Pharmacokinetics) Ivermax is primarily metabolized by CYP3A4. CYP2D6 and CYP2E1 were also shown to be involved in the metabolism of Ivermax but to a significantly lower extent compared to CYP3A4. Concentrations of Ivermax do not significantly inhibit the metabolizing activities of CYP3A4, CYP2D6, CYP2C9, CYP1A2, and CYP2E1. Ivermax is a member of the avermectin class of broad-spectrum antiparasitic agents which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the _parasite_. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The selective activity of compounds of this class is attributable to the facts that some mammals do not have glutamate-gated chloride channels and that the avermectins have a low affinity for mammalian ligand-gated chloride channels. In addition, Ivermax does not readily cross the blood-brain barrier in humans. Strongyloidiasis of the intestinal tract. IVERMAX is indicated for the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode _ parasite_ _ Strongyloides _ _stercoralis_. COMPOSITION Les hele dokumentet