ISOFLURANE- isoflurane liquid

Land: USA

Språk: engelsk

Kilde: NLM (National Library of Medicine)

Aktiv ingrediens:

Isoflurane (UNII: CYS9AKD70P) (Isoflurane - UNII:CYS9AKD70P)

Tilgjengelig fra:

Halocarbon Products Corp.

Administreringsrute:

RESPIRATORY (INHALATION)

Resept typen:

PRESCRIPTION

Indikasjoner:

Isoflurane, USP is used for induction and maintenance of general anesthesia in horses and dogs. Isoflurane, USP is contraindicated in horses and dogs with known sensitivity to isoflurane or to other halogenated agents.

Produkt oppsummering:

Isoflurane, USP is packaged in 100 mL (NDC 12164-003-10) and 250 mL (NDC 12164-003-25) amber-colored bottles. Store at room temperature 15°-30°C (59° -86° F).

Autorisasjon status:

Abbreviated New Animal Drug Application

Preparatomtale

ISOFLURANE- ISOFLURANE LIQUID
HALOCARBON PRODUCTS CORP.
----------
ISOFLURANE, USP
INHALATION ANESTHETIC
FOR USE IN HORSES AND DOGS
WARNING
Not for use in horses intended for food.
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
Isoflurane, USP is a nonflammable, nonexplosive general inhalation
anesthetic agent. Its chemical name
is 1-chloro-2,2,2- trifluoroethyl difluoromethyl ether, and its
structural formula is:
Each mL contains 99.9% isoflurane.
Some physical constants are:
Molecular weight
184.5
Boiling point at 760 mm Hg
48.5°C
Refractive index
1.2990-1.3005
Specific gravity 25°/25°C
1.496
Vapor pressure in mm Hg
20°C
238
25°C
295
30°C
367
35°C
450
Partition coefficients at 37°C:
Water/gas
0.61
Blood/gas
1.43
Oil/gas
90.8
Partition coefficients at 25°C - rubber and plastic:
Conductive rubber/gas
62.0
Butyl rubber/gas
75.0
Polyvinyl chloride/gas
110.0
Polyethylene/gas
~ 2.0
Polyurethane/gas
~ 1.4
*
*
Polyolefin/gas
~ 1.1
Butyl acetate/gas
~ 2.5
Purity by gas chromatography
>99.9%
Lower limit of flammability in oxygen or
nitrous oxide at 9 joules/sec. and 23°C
None
Lower limit of flammability in oxygen or
nitrous oxide at 900 joules/sec. and 23°C
Greater than useful
concentration in
anesthesia
MAC (Minimum Alveolar Concentration) is 1.31% in horses and 1.28% in
dogs .
Isoflurane is a clear, colorless, stable liquid containing no
additives or chemical stabilizers. Isoflurane
has a mildly pungent, musty, ethereal odor. Samples stored in indirect
sunlight in clear, colorless glass
for five years, as well as samples directly exposed for 30 hours to a
2 amp, 115 volt, 60 cycle long
wave U.V. light were unchanged in composition as determined by gas
chromatography. Isoflurane in
one normal sodium methoxide-methanol solution, a strong base, for over
six months consumed
essentially no alkali, indicative of strong base stability. Isoflurane
does not decompose in the presence
of soda lime (at normal operating temperatures), and does not attack
aluminum