HUMAN ALBUMIN OCTAPHARMA INFUSION 25%

Land: Singapore

Språk: engelsk

Kilde: HSA (Health Sciences Authority)

Aktiv ingrediens:

ALBUMIN (HUMAN) (min. 96% total protein)

Tilgjengelig fra:

WELLCHEM PHARMACEUTICALS PTE LTD

ATC-kode:

B05AA01

Dosering :

228-262 g/l

Legemiddelform:

INJECTION

Administreringsrute:

INTRAVENOUS

Resept typen:

Prescription Only

Produsert av:

OCTAPHARMA PHARMAZEUTIKA PRODUKTIONSGES MBH

Autorisasjon dato:

2002-05-28

Informasjon til brukeren

INSTRUCTIONS FOR USE
HUMAN ALBUMIN OCTAPHARMA 25%
INFUSION BOTTLE
PHARMACEUTICAL FORM
Solution for infusion
MANUFACTURER
Octapharma Pharmazeutika Produktionsges.m.b.H.
Oberlaaer Strasse 235, A-1100 Vienna, Austria
COMPOSITION
1000 ml infusion solution contain:
ALBUMIN (AT LEAST 96% OF TOTAL PROTEIN)
228 - 262 g
Protein
238 - 262 g
Sodium
142.5 - 157.5 mmol
Potassium
max. 2.0 mmol
N-acetyl-DL-tryptophanate
max. 0.08 mmol / g albumin
Sodium caprylate
max. 0.08 mmol / g albumin
Contains no preservatives agents.
PROPERTIES AND EFFICACY
HUMAN ALBUMIN Octapharma 25% is free of isoagglutinins and other
hemagglutinins so that it can be infused independent of the blood
group and
rhesus characteristics of the recipient.
In terms of quantity, human albumin (MW 66300 D) accounts for about
60% of
the plasma proteins in human serum and therefore constitutes the major
portion
of plasma proteins. The distribution of the total albumin between the
intravascular
and extravascular human albumin pool under physiological conditions is
40:60
and constitutes about 4.5 to 5 g per kilogram body weight. The
biosynthesis of
albumin occurs in the liver; the biological half-life is about 18
days.
Physiological functions of albumin:
1. Maintenance of colloidal osmotic pressure: 40 to 45 g/l albumin
corresponds
to a colloid osmotic pressure of 16 - 18 mm Hg, i.e. 60 to 70% of the
total
normal colloid osmotic pressure (COP) of 26 to 28 mm Hg.
2. Regulation of intravascular and extravascular fluid volume: 1 g of
human
albumin binds about 18 ml of water. The application of hyperoncotic
solutions
increases the COP and causes a transcapillary reflux of water from the
extravasal
space into the vascular system, thus increasing the circulating
volume.
3. Buffer effect: Under normal physiological conditions, plasma
proteins serve
as carriers of positively and negatively charged groups and are
responsible for
about 1/6 of the buffer capacity of plasma. At pH 7.4, proteins mainly
have
anionic properties.
4. Transport function: Albumin is the most impo