Cosopt

Land: Australia

Språk: engelsk

Kilde: Department of Health (Therapeutic Goods Administration)

Aktiv ingrediens:

Timolol maleate; Dorzolamide hydrochloride

Tilgjengelig fra:

Merck Sharp & Dohme Australia Pty Ltd

Klasse:

Medicine Listed (Export Only)

Informasjon til brukeren

COSOPT
®

_Dorzolamide hydrochloride/Timolol maleate_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about COSOPT. It does not
contain all the available information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using COSOPT
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
USING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT COSOPT IS USED
FOR
COSOPT is used to lower raised
pressure in the eye and to treat
glaucoma. Glaucoma is a condition
in which the pressure of fluid in the
eye may be high. However, some
people with glaucoma may have
normal eye pressure. Also, some
people with raised eye pressure may
not have glaucoma.
Glaucoma is usually caused by a
build-up of the fluid which flows
through the eye. This build up occurs
because the fluid drains out of your
eye more slowly than it is being
pumped in. Since new fluid continues
to enter the eye, joining the fluid
already there, the pressure continues
to rise. This raised pressure may
damage the back of the eye resulting
in gradual loss of sight. Damage can
progress so slowly that the person is
not aware of this gradual loss of
sight. Sometimes even normal eye
pressure is associated with damage to
the back of the eye.
There are usually no symptoms of
glaucoma. The only way of knowing
that you have glaucoma is to have
your eye pressure, optic nerve and
visual field checked by an eye
specialist or optometrist. If glaucoma
is not treated it can lead to serious
problems. You may have no
symptoms but eventually glaucoma
can lead to total blindness. In fact,
untreated glaucoma is one of the
most common causes of blindness.
Although COSOPT helps control
your glaucoma it does not cure it.
For more information about
glaucoma, contact Glaucoma
Australia Inc., PO Box 420, Crows
Nest 1585, telephone 02

Preparatomtale

WPC-MK0507A-OS-092012 

PRODUCT INFORMATION 

COSOPT


EYE DROPS 

{dorzolamide (as hydrochloride) and timolol (as maleate)} 

NAME OF THE MEDICINE 

COSOPT
® 
contains dorzolamide
(as hydrochloride) and timolol (as maleate). 

_Dorzolamide Hydrochloride _

Dorzolamide hydrochloride is described
chemically as: (4_S_-_trans_)-4-(ethylamino)-5,6-
dihydro-6-methyl-4_H_-thieno [2,3-_b_]thiopyran-2-sulfonamide
7,7-dioxide monohydrochloride. 

Its empirical formula is C10H17N2O4S3Cl and
its structural formula is: 

_  _
CAS Registry Number:130693-82-2 

_Timolol Maleate _
_ _
_ _
_ _
Timolol  maleate  is  described  chemically  as:  (_S_)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-
morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol,(_Z_)-2-butenedioate  (1:1)  (salt).    Timolol 
maleate possesses an asymmetric carbon atom in the structure and is provided as the levo 
isomer.  

The empirical formula is C13H24N4O3SC4H4O4 and
the structural formula is: 

CAS Registry Number: 26921-17-5 

DESCRIPTION 

Dorzolamide hydrochloride has a molecular weight of 360.91.  It is a white to off-white, free 
flowing  crystalline  powder,  which  is  soluble  in  water  and  slightly  soluble  in  methanol  and 
ethanol. 

Timolol  maleate  has  a  molecular  weight  of  432.50.    It  is  a  white,  odourless,  crystalline 
powder which is soluble in water, methanol, and alcohol. 

WPC-MK0507A-OS-092012 
2 

COSOPT is supplied as a
sterile, isotonic, buffered, slightly viscous, aqueous
solution.  Each 
millilitre  of  COSOPT  contains  20.00  mg  dorzolamide  (22.26  mg  of  dorzolamide 
hydrochloride) and 5.00 mg timolol (6.83 mg
of timolol maleate) as the active ingredients. 

COSOPT  contains  the  following  inactive  ingredients:  sodium