Land: Indonesia
Språk: indonesisk
Kilde: Badan Pengawas Obat dan Makanan RI - Indonesian Food and Drug Supervisory Agency
CIPROFLOXACIN HYDROCHLORIDE
BAYER INDONESIA - Indonesia
CIPROFLOXACIN HYDROCHLORIDE
500 MG
TABLET SALUT SELAPUT
DUS, 2 BLISTER @ 10 TABLET SALUT SELAPUT
2019-04-12
CIPROXIN ® FILM-COATED TABLET Important information, please read carefully! COMPOSITION Ciproxin ® 500: 1 film-coated tablet contains 582 mg ciprofloxacin hydrochloride monohydrate, correspond to 500 mg ciprofloxacin. PHARMACOLOGICAL PROPERTIES Pharmacotherapeutic group: Fluoroquinolones ATC Code: J01MA02 Ciprofloxacin is a new substance developed by Bayer AG belonging to the quinolone carboxylic acid group. The substance has a good bactericidal effect against a broad spectrum of bacteria. PHARMACODINAMIC PROPERTIES MECHANISM OF ACTION The bactericidal action of ciprofloxacin results from inhibition of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV), which are required for bacterial DNA replication, transcription, repair, and recombination. MECHANISM OF RESISTANCE _In-vitro _resistance to ciprofloxacin can be acquired through a stepwise process by target site mutations in both DNA gyrase and topoisomerase IV. The degree of cross-resistance between ciprofloxacin and other fluoroquinolones that results is variable. Single mutations may not result in clinical resistance, but multiple mutations generally result in clinical resistance to many or all active substances within the class. Impermeability and/or active substance efflux pump mechanisms of resistance may have a variable effect on susceptibility to fluoroquinolones, which depends on the physiochemical properties of the various active substances within the class and the affinity of transport systems for each active substance. All _in-vitro _mechanisms of resistance are commonly observed in clinical isolates. Resistance mechanisms that inactivate other antibiotics such as permeation barriers (common in _Pseudomonas aeruginosa_) and efflux mechanisms may affect susceptibility to ciprofloxacin. Plasmid-mediated resistance encoded by qnr-genes has been reported. The bacterial genus and species listed below have been shown to commonly be susceptible to ciprofloxacin in vitro: AEROBIC GRAM-POSITIVE MICROORGANISMS _Bacillus anthracis _ _Streptococ Les hele dokumentet