CHLORAMINE TABLET

Land: Malaysia

Språk: engelsk

Kilde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktiv ingrediens:

CHLORPHENIRAMINE MALEATE

Tilgjengelig fra:

DUOPHARMA MANUFACTURING (BANGI) SDN BHD

INN (International Name):

CHLORPHENIRAMINE MALEATE

Enheter i pakken:

1000 Tablet Tablets; 10 x 10 Tablets

Produsert av:

DUOPHARMA MANUFACTURING (BANGI) SDN BHD

Informasjon til brukeren

_Consumer Medication Information Leaflet (RIMUP) _
1
CHLORAMINE TABLET/SYRUP
Chlorpheniramine Maleate (4mg, 4mg/5ml, 2.5mg/5ml)
WHAT IS IN THE LEAFLET
1.
What Chloramine is used for
2.
How Chloramine works
3.
Before you use Chloramine
4.
How to use Chloramine
5.
While you are using it
6.
Side effects
7.
Storage
and
disposal
of
Chloramine
8.
Product description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT CHLORAMINE IS USED FOR
Chloramine
is
used
for
the
prevention and treatment:
•
perennial
(throughout
the
year)
and
seasonal
allergic
rhinitis
(inflammation
of
mucous membrane inside the
nose)
•
vasomotor
(non-allergic)
rhinitis
•
allergic
conjunctivitis
(eye
inflammation)
•
sneezing
and
runny
nose
associated with common cold
It is also used for relief of:
•
pruritus (itching)
•
urticaria (a red, raised, itchy
rash)
•
angioedema (swelling of the
deeper layers of the skin)
•
dermatographism (pressure or
friction on skin causes raised,
reddish marks)
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor
may
have
prescribed
this
medicine for another reason.
HOW CHLORAMINE WORKS
The
name
of
your
medicine
is
Chloramine. It contains the active
ingredient
chlorpheniramine
maleate which is an antihistamine.
Histamine is a chemical released
into the body during an allergic
reaction.
It
causes
itching
and
inflammation.
Chloramine works by blocking the
effects of histamine, calming down
the
body's
allergic
reaction
and
starting to relieve the symptoms.
BEFORE YOU USE CHLORAMINE
-
_When you must not use it_
Do not take this medicine if:
•
you are hypersensitive to, or
have had an allergic reaction
to chlorpheniramine or any of
the
ingredients
listed
at
the
end of this leaflet.
•
you
are
taking
a
class
of
medicine
known
as
monoamine oxidase inhibitors
(MAOIs)
(often
taken
for
depression), or you have taken
such
a
medicine
within
the
last 14 days.
•
the expiry date (EXP) printed
on the pack has passed.
•
the packaging is tor

Preparatomtale

CHLORAMINE TABLET
A 6.5 mm diameter, round, convex, scored, marked 'UP' yellow tablet.
_Each tablet contains Chlorpheniramine maleate 4 mg._
Chlorpheniramine
is
used
for
the
prophylactic
and
symptomatic
treatment
of
perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic
conjunctivitis due
to inhalant allergens and foods and sneezing and rhinorrhoea
associated with the
common cold. It is also indicated for the symptomatic relief of
pruritus associated with
allergic reactions and of mild, uncomplicated allergic skin
manifestations of urticaria
and angioedema, in dermatographism, and in urticaria associated with
transfusions. It
is used as adjunctive therapy to epinephrine and other standard
measures for
anaphylactic reactions after the acute manifestations have been
controlled, and to
ameliorate the allergic reactions to blood or plasma.
Chlorpheniramine is a propylamine derived antihistamine. Its use in
the treatment of
allergy acts by competing with histamine H1-receptor sites on effector
cells. It does not
inactivate histamine or prevent its synthesis or release. It thereby
prevents, but do not
reverse, responses mediated by histamine alone. Antihistamines
antagonise, in varying
degrees, most of the pharmacological effects of histamine, including
urticaria, pruritus
and vasodilation.
Chlorpheniramine maleate is absorbed relatively slowly from the
gastro-intestinal
tract, peak plasma concentrations occuring about 2-6 hours after
administration by
mouth while peak effect occurs at 6 hours after administration. The
onset of action of
chlorpheniramine
is
between
15-60
minutes.
Bioavailability
is
low,
values
of
25%-50% having been reported. About 72% of chlorpheniramine in the
circulation is
bound to plasma proteins. There is wide interindividual variation in
the pharmacoki-
netics of chlorpheniramine; values ranging from 14-25 hours have been
reported for
the half-life. Chlorpheniramine is widely distributed in the body,
including passage
into the CNS. Chlorpheniramine maleate is extensively metaboli