Atorvastatin Pfizer

Land: Australia

Språk: engelsk

Kilde: Department of Health (Therapeutic Goods Administration)

Aktiv ingrediens:

Atorvastatin calcium

Tilgjengelig fra:

Pfizer Australia Pty Ltd

Klasse:

Medicine Registered

Informasjon til brukeren

ATORVASTATIN
PFIZER
®

_Atorvastatin calcium_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some of the
more common questions about
Atorvastatin Pfizer.
It does not contain all of the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Atorvastatin
Pfizer against the benefits he/she
expects it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT ATORVASTATIN
PFIZER IS USED FOR
Atorvastatin Pfizer is used to lower
high cholesterol levels.
Atorvastatin Pfizer is also used to
help reduce the risk of having a heart
attack or stroke in people who have
high blood pressure and coronary
heart disease (CHD) or who are at
risk of CHD. Examples of risk
factors for CHD include diabetes, a
history of stroke, or small blood
vessel disease.
_WHAT IS CHOLESTEROL?_
Everyone has cholesterol in their
blood. It is a type of blood fat needed
by the body for many things, such as
building the cell lining, making bile
acids (which help to digest food) and
some hormones. However, too much
cholesterol can be a problem.
Cholesterol is present in many foods
and is also made in your body by the
liver. If your body makes too much
cholesterol or you have too much
cholesterol in your diet, then your
level becomes too high.
High cholesterol is more likely to
occur with certain diseases or if you
have a family history of high
cholesterol.
There are different types of
cholesterol. LDL, or low-density
lipoprotein, is the 'bad' cholesterol
that can block your blood vessels.
HDL, or high density lipoprotein,
cholesterol is the 'good' cholesterol
that is thought to remove the bad
cholesterol from the blood vessels.
When you have high levels of 'bad'
cholesterol in your blood, it may
begin to 'stick' to the inside of your
blood vessels instead of being carried
to

Preparatomtale

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PRODUCT INFORMATION 
ATORVASTATIN PFIZER
®
 (ATORVASTATIN CALCIUM) 
NAME OF THE MEDICINE 
ATORVASTATIN  PFIZER  atorvastatin  (as  calcium)  10 mg,  20 mg,  40 mg  and  80 mg 
tablets. 
ATORVASTATIN  PFIZER  contains  the  active  ingredient  atorvastatin  calcium.    The 
structural formula of atorvastatin calcium is shown below: 
NHC
N
O
CH
CH
3
CH
3
CH
2
CH
2
CH
2
CH
2
CH
CH
C
O
O
-
F
2
•Ca
•3H O
2
2+
OH
OH

Chemical name: 
[R-(R*,R*)]-2-(4-fluorophenyl)-ß,

-dihydroxy-5-(1-methylethyl)- 
3-phenyl-4-[(phenylamino) carbonyl] -1H-pyrrole -1-heptanoic 
acid, calcium salt (2:1) 
Molecular formula: 
(C
33
H
34
FN
2
O
5
)
2
Ca.3H
2
O 
Molecular weight: 
1209.42 
CAS registry number: 134523-03-8. 
DESCRIPTION 
Atorvastatin calcium is a white to off-white crystalline powder that is practically insoluble in 
aqueous  solutions  of  pH 4  and  below.    Atorvastatin  calcium  is  very  slightly  soluble  in 
distilled  water,  pH 7.4  phosphate  buffer,  and  acetonitrile,  slightly  soluble  in  ethanol  and 
freely soluble in methanol. 
ATORVASTATIN PFIZER tablets contain atorvastatin calcium equivalent to 10, 20, 40 and 
80 mg  atorvastatin.    The  tablets  also  contain  the  following  inactive  ingredients:  calcium 
carbonate,  microcrystalline  cellulose,  lactose,  croscarmellose  sodium,  polysorbate 80, 
hydroxypropylcellulose,  magnesium  stearate,  Opadry  White  YS-1-7040  and  Simethicone 
Emulsion. 
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PHARMACOLOGY 
MECHANISM OF ACTION 
Atorvastatin  is  a  synthetic  lipid-lowering  agent.    Atorvastatin  is  an  inhibitor  of  HMG-CoA 
reductase,  the  rate-limiting  enzyme  that  converts  3-hydroxy-3