APO-PERPHENAZINE TABLET 4MG

Land: Malaysia

Språk: engelsk

Kilde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktiv ingrediens:

PERPHENAZINE

Tilgjengelig fra:

PHARMAFORTE (MALAYSIA) SDN. BHD.

INN (International Name):

PERPHENAZINE

Enheter i pakken:

1000 Tablet Tablets; 500 Tablets

Produsert av:

APOTEX INC

Preparatomtale

APO‐PERPHENAZINE
PERPHENAZINE TABLETS USP 4MG
ANTIPSYCHOTIC‐ANTIEMETIC‐ANTIANXIETY
PHARMACOLOGY: Perphenazine is a piperazine phenothiazine derivative.
Numerous phenothiazine derivatives are in current use. They
resemble chlorpromazine in action but differ from it in potency,
clinical indications, and toxicity.
The pharmacologic effects of the phenothiazine tranquilizers are quite
complex. In addition to
their behavioral effects, these drugs
are potent anti‐emetics and have important actions on the autonomic
nervous system at various levels. In large doses, they also
produce significant toxic side effects such as parkinsonism.
The various phenothiazines differ from the standpoint of their
potency, extrapyramidal effects, and sedative effects. The piperazines
are more potent than other phenothiazines, cause significant
extrapyramidal effects, and are not very sedative.
Since the extrapyramidal effects may be antagonized by the
anticholinergic drugs, it is probable that differences in causing
extrapyramidal side effects reflect intrinsic anticholinergic potency
of some of the phenothiazines.
Chlorpromazine will be discussed as
the prototype of the phenothiazine drugs.
Chlorpromazine an aliphatic or dimethylaminopropyl phenothiazine, is a
sedative antipsychotic drug. In addition to its usefulness in
agitated psychotic persons, the drug has other medical applications
such as prevention of nausea and vomiting. It is used also for its
ability to potentiate the actions
of other drugs such as anesthetics.
The pharmacologic effects of chlorpromazine and other phenothiazines
are antipsychotic, abnormal movements, anticholinergic and
antiadrenergic, interference with temperature regulation, antiemetic,
and endocrine.
Chlorpromazine, the prototype phenothiazine, is absorbed somewhat
erratically when given by mouth. Peak plasma levels occur in 2
to 4 hours, a
plateau is maintained for several hours, and predose levels occur in
12 hours. Plasma half‐lives are extremely variable,
averaging 9 hours.
The distribution of