APO-Meloxicam Capsules

Land: Australia

Språk: engelsk

Kilde: Department of Health (Therapeutic Goods Administration)

Aktiv ingrediens:

Meloxicam

Tilgjengelig fra:

Apotex Pty Ltd

Klasse:

Medicine Registered

Informasjon til brukeren

APO-MELOXICAM

_CAPSULES_
_Contains the active ingredient meloxicam_
CONSUMER MEDICINE INFORMATION

_FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about meloxicam. It does
not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
this medicine may be available.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet,
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is APO-
Meloxicam. It contains the active
ingredient meloxicam.
It is used to treat the symptoms of
•
osteoarthritis
•
rheumatoid arthritis
Both diseases mainly affect the joints
causing pain and swelling.
Although meloxicam can relieve
symptoms such as pain and
inflammation, it will not cure your
condition.
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor may have prescribed this
medicine for another reason.
This medicine is available only with
a doctor's prescription.
_HOW IT WORKS_
Meloxicam belongs to a family of
medicines called Non-Steroidal Anti-
inflammatory Drugs (NSAIDs).
These medicines work by relieving
pain and inflammation.
There is no evidence that this
medicine is addictive.
_USE IN CHILDREN_
DO NOT GIVE MELOXICAM TO CHILDREN
AND ADOLESCENTS UNDER 18 YEARS OF
AGE.
BEFORE YOU TAKE THIS
MEDICINE
_WHEN YOU MUST NOT TAKE

Preparatomtale

Product Information – Australia 
APO-Meloxicam capsules 
Page 1 
APO-MELOXICAM CAPSULES 

NAME OF THE MEDICINE 
Meloxicam 

Chemical Name: 
4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-
carboxamide-1,1-dioxide. 

Structural Formula: 

Molecular Formula: 
C
14
H
13
N
3
O
4
S
2. 

Molecular Weight: 
351.4 

CAS Registry Number: 
71125-38-7 

DESCRIPTION 
Meloxicam is a pastel yellow solid with pKa values of 1.09 and
4.18 and a melting point of about 
256°C.  The substance is practically insoluble in water, soluble in dimethylformamide, slightly soluble 
in chloroform and acetone and very slightly soluble in methanol.
 There are no chiral centres. 

PHARMACOLOGY 
PHARMACOLOGICAL ACTIONS 
Meloxicam  is a
non-steroidal anti-inflammatory drug (NSAID) of the enolic acid
class, which has 
shown anti-inflammatory, analgesic and antipyretic properties in
animals.  Meloxicam showed anti-
inflammatory activity in all standard models of inflammation.  A
common mechanism for the above 
effects may exist in the ability of meloxicam to
inhibit the biosynthesis of prostaglandins, known 
mediators of inflammation, by inhibition of cyclooxygenase
(COX). 

Comparison of the ulcerogenic dose and the anti-inflammatory effective dose in rat adjuvant arthritis 
model confirmed a greater therapeutic margin in
animals over other NSAIDs (piroxicam, diclofenac, 
naproxen, flurbiprofen).  In rats, meloxicam showed
greater inhibitory effect on prostaglandin 
biosynthesis at the site of inflammation
than in the gastric mucosa or the kidney. 

Selective inhibition of the COX-2 isoenzyme, relative to
COX-1, by meloxicam has been demonstrated 
_in vitro _on various cell systems: guinea pig
macrophages, bovine aortic endothelial cells (for testing of 
COX-1 activity), mouse macrophages (for testing for COX