Land: Malaysia
Språk: engelsk
Kilde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
AMLODIPINE BESILATE
JETPHARMA SDN. BHD.
AMLODIPINE BESILATE
140Tablet Tablets
INTAS PHARMACEUTICALS LIMITED
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ _ _ AMTAS TABLET Amlodipine Besylate Tablets 5 mg and 10 mg. _____________________________________________________________________________________________ 1 WHAT IS IN THIS LEAFLET 1. What Amtas tablet is used for 2. How Amtas works 3. Before you use Amtas. 4. How to use Amtas 5. While you are using Amtas tablet. 6. Side effects 7. Storage and disposal of Bical tablet. 8. Product description. 9. Manufacturer and Product registration holder 10. Date of revision WHAT AMTAS TABLETS IS USED FOR This medicine is used to treat patients suffering from: 1. Mild to moderate high blood pressure. 2. Angina pectoris: (a) Chest pain due to narrowing of the coronary arteries of the heart muscle (chronic stable angina). (b) The rarer form of chest pain caused by cramping of the coronary arteries of the heart muscle (vasospastic angina / prinzmetal's or variant angina) HOW AMTAS WORKS Amlodipine is designed to work with your body by relaxing your body vessels, causing them to widen. This allows your blood to flow more easily, which in turns lets your heart work more efficiently, placing less strain on your arteries and heart. By reducing your heart workload, Amlodipine helps to keep your heart healthy. BEFORE YOU USE AMTAS _- When you must not use it _ - If you have ever had an allergic reaction to Amlodipine or other calcium channel blockers. - If you are allergic to any of the ingredients listed at the end of this leaflet. _- Before you start to use it _ Tell your healthcare provider about all of your medical conditions, if you: • are pregnant or intend to become pregnant while taking Amlodipine. • are breastfeeding or wish to breastfeed. • are allergic to any foods, dyes, preservatives or any other medicines. • have any health problems, including: - heart disease such as heart failure -liver problems - any other allergies _- Taking other medicines _ _ _ Taking other medicines: Some medicines may interact with Amlodipine. This means that the action of both medicines ca Les hele dokumentet
AMTAS-5/10 Amlodipine Besylate Tablets USP 5 mg and 10 mg FOR SPECIALIST'S USE ONLY Active Ingredient: Amlodipine Besylate The uncoated tablets contain amlodipine besylate USP equivalent to 5 mg and 10 mg amlodipine DOSAGE FORM: Tablet THERAPEUTIC CLASS: Anti hypertensive Anti anginal DESCRIPTION: AMTAS 5, 10: White to off white, round, flat, uncoated tablets with bevelled edges having breakline on one side and plain on other side. PHARMACOLOGY PHARMACODYNAMICS: MECHANISM OF ACTION Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Experimental data suggests that Amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects can be detected in vitro but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by Amlodipine. Within the physiological pH range, Amlodipine is an ionized compound (pKa = 8.6), and its kinetic interaction with the calcium channel receptor is characterised by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. The precise mechanisms by which Amlodipine relieves angina have not been fully delineated, but are thought to include the following : Exertional Angina : In patients with exertional angina, Amlodipine reduces the total peripheral resistance (after load) aga Les hele dokumentet