AMOX-500MG Water Soluble Powder

Land: Malaysia

Språk: engelsk

Kilde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktiv ingrediens:

AMOXICILLIN TRIHYDRATE

Tilgjengelig fra:

Life Biopharma Sdn. Bhd.

INN (International Name):

AMOXICILLIN TRIHYDRATE

Enheter i pakken:

200.00 mcg/mL; 500.00 mcg/mL; 100.00 mcg/mL; 1000.00 mcg/mL

Produsert av:

Life Biopharma Sdn. Bhd.

Preparatomtale

Antimicrobial
Therapy
in
Veterinary
Medicine
THIRD
EDITION
Edited
by
fohn
F.
Prescott
M.A.,
Vet.M.B.,
Ph.D.
f.
Desmond
Baggot
M.V.M.,
Ph.D.,
D.Sc.,
F.R.C.V.S.
Robert
D. Walker
M.Sc.,
P h . D .
with
Thirty
Contributors
(D
1"#n"7:?,::*P::;;
1 1 6
NTIMJCROBIALTHERAPY
N V F T E R I N A R Y M E D C I N E
beta-lactamase
is now lvidespread
in
S.
d /ells,
pafiicularly in clnlical
iso-
lates, as a result of baciedophage- or
plasmid mediated resistance.
Among
Gram-negative
bacieria,
plasmids
encoding
beta-lactamases
have
also become
widespread and arc the cause
of extensive
acquired resis-
tance.
Modification oI PBPS
is recoglized to be
increasingly
importanl as
anothel mechanism
of resistance
to
penarn penicillins.
The most impor-
tant example in human medicine is methicillin
(oxacillin)
resistance
in
S. alr/ers
(MRSA)
but resistance
because
of this mechanjsm
has not been
well documented
in animal paihoSens.
Pharmacokin€tic
Prooerties
The penicillins are organic acids thai are
tenerally
available
as the
sodium or
potassiurn
salt of the free acid. In dry. crystalline
form, peni-
cillins are
s
table
but lose
their activity rapidly when dissolved.
Apart from
the
jsoxazolyl
penicilljns (cloxacillin,
dicloxacilli& oxacillin) and
peni-
cillh
V
acid hydrolysis limits the systemic
availability of mostpenicillins
from
oral
preparations.
The penicilins
(pK"
2.7) are predominantly ion-
ized
in
plasma,
have relatively small apparent volumes oI distribution
(0.2
0.3 l/kg), and have short hal
ives
(0.s
1.2 hours)
jn
a[ species
oI
domestic animals. Afier
absorpiion, ihey are widely
distributed
in ihe
extracellular
fluids of the body,
but they
cross
biologic memb(anes
pooriy
becarse
they
are ionized and
poorly
lipid soluble.
Concentration
h milk,
for
example,
is about one-Iifth that of serum.
Eniry across
biologic mem-
branes
or through the blood-brain or blood-cerebrospinal
fluid barrier is
enhanced
by inflammation,
so thai inhibitory drug concentrations
maybe
attained
ai these
sites,
which are normally inaccessible
to penicillin.
Pen