Terry White Chemists Diltiazem tablets

Land: Australië

Taal: Engels

Bron: Department of Health (Therapeutic Goods Administration)

Werkstoffen:

Diltiazem hydrochloride

Beschikbaar vanaf:

Apotex Pty Ltd

klasse:

Medicine Registered

Bijsluiter

TERRY WHITE CHEMISTS
DILTIAZEM TABLETS

_Contains the active ingredient diltiazem hydrochloride_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about diltiazem. It does not
contain all the available information.
It does not take the place of talking to
your doctor or pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
this medicine may be available.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet,
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information.
You can also download the most up
to date leaflet from
www.apotex.com.au.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT DILTIAZEM IS USED
FOR
The name of your medicine is Terry
White Chemists Diltiazem. It
contains the active ingredient
diltiazem hydrochloride.
It is used to treat:
•
hypertension (high blood
pressure)
•
angina.
HYPERTENSION:
Everyone has blood pressure. This
pressure helps move your blood
around your body. Your blood
pressure may be different at different
times of the day, depending on how
busy or worried you are. You have
hypertension (high blood pressure)
when your blood pressure stays
higher than is needed, even when you
are calm and relaxed.
There are usually no symptoms of
hypertension. The only way of
knowing that you have hypertension
is to have your blood pressure
checked on a regular basis. You may
feel fine and have no symptoms, but
if high blood pressure is not treated,
it can lead to serious health
problems.
ANGINA:
Angina is a pain or uncomfortable
feeling in the chest, often spreading
to

Productkenmerken

Product Information 
– Australia_ _
Terry White Chemists Diltiazem Tablets  
Page 1 
TERRY WHITE CHEMISTS DILTIAZEM TABLETS 

NAME OF THE MEDICINE 
Diltiazem hydrochloride.  

Chemically  diltiazem  hydrochloride  is  the  hydrochloride  salt  of  (2S,3S)-5-(2-dimethylaminoethyl) 
2,3,4,5-tetrahydro-2- (4-methoxyphenyl)-4-oxo-1,5,-benzothiazepin-3-yl acetate. 

N
S
NMe
2
H
OAc
OMe
O
H
1
HCl

Molecular Formula:  
C
22
H
26
N
2
O
4
S.HCl 

CAS Number:  
33286-22-5 

Diltiazem hydrochloride has a molecular weight of 451. 

DESCRIPTION 
Diltiazem hydrochloride is a calcium ion influx inhibitor
(slow channel blocker or calcium antagonist). 
Diltiazem  hydrochloride  is  a  white  to  off-white  crystalline  powder  with  a  bitter  taste.  It  is  soluble  in 
water, methanol, and chloroform.  

PHARMACOLOGY 
PHARMACODYNAMICS  
The  therapeutic  benefits  achieved  with  diltiazem  are  believed  to  be  related  to  its  ability  to  inhibit  the 
influx of calcium ions during membrane depolarisation of cardiac and
vascular smooth muscle.  

Mechanisms of Action 
Although precise mechanisms of its antianginal actions are still being delineated, diltiazem is believed 
to act in the following ways: 

1.  
_Angina due to Coronary Artery Spasm:_  

Diltiazem  has  bee  shown  to  be  a  potent  dilator  of  coronary  arteries  (both  epicardial  and 
subendocardial). Spontaneous and ergometrine-induced coronary artery spasm are inhibited by 
diltiazem. 

2.  
_Exertional Angina:_  

Diltiazem has been shown to produce increases in exercise tolerance, probably due to its ability 
to  reduce  myocardial  oxygen  demand  and  increase  oxygen  supply.  This  is  accomplished  via 
reductions  in  heart  rate �