SULFARIM 48% WW POWDER

Land: Maleisië

Taal: Engels

Bron: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Werkstoffen:

SULFADIMIDINE SODIUM/SULFAMETHAZINE SODIUM; TRIMETHOPRIM

Beschikbaar vanaf:

Dexchem Industries Sdn Bhd

INN (Algemene Internationale Benaming):

SULFADIMIDINE SODIUM/SULFAMETHAZINE SODIUM; TRIMETHOPRIM

Eenheden in pakket:

500 gm; 100 gm; 1 kg

Geproduceerd door:

Dexchem Industries Sdn Bhd

Productkenmerken

VETERINARY PACKAGE INSERT
PRODUCT NAME:
SULFARIM 48% W/W POWDER
ACTIVE INGREDIENT:
Sulfadimidine Sodium…. 431mg
(Sulfadimidine…………….400mg)
Trimethoprim……………..80mg
PRODUCT DESCRIPTION:
A white colour and odourless powder.
TARGET SPECIES:
Bovine, Equine, Poultry, Swine, Others: Horses, Calves, Pigs and
Poultry
PHARMACODYNAMICS:
Sulfadimidine is a pyrimidine sulphonamide antimicrobial agent.
Sulfonamides,
being structural analogues of para-aminobenzoic acid (PABA),
competitively
inhibit the incorporation of PABA into dihydropteric acid, the
precursor of folic
acid. Subsequent reduction in the level of folic acid reduces the
production of
nucleic acids in sensitive bacteria. Mammalian cells require preformed
folic acid
and
thus
are
unaffected
by
sulphonamides.
The
antibacterial
actions
of
sulphonamides are reduced in the presence of blood, pus and tissue
breakdown
products, which contain purines and thymidine, as the bacterial
requirement of
folic acid is decreased in such media.
Trimethoprim is a diaminopyrimidine antimicrobial agent. It acts by
preventing
the reduction of dihydrofolate to tetrahydrofolate which is required
by bacteria
for biosynthesis of purines, pyrimidines and some amino acids.
Sulfadimidine and trimethoprim have similar antibacterial spectra,
trimethoprim
being approximately 20 times more potent than sulfadimidine. The
combination
blocks two
sequential
obligate
enzymatic
reaction in
the
microbial
folate
synthetic pathway, A synergistic action is demonstrated by the
enhanced
antimicrobial
activity
(potentiation)
of
the combination
compared
with
the
antimicrobial activity of either agent singly. The minimum inhibitory
(MICs) of the
combination for susceptible bacteria are substantially lower than
those of either
of the individual agents. The combination of sulphonamide/trimethoprim
is
bactericidal
while
either
drug
alone
is
bacterionstatic.
Folate-synthesising
bacteria which are resistant or moderately resistant to either drug
alone are
frequently susceptible to the combinati