SEVORANE

Land: Israël

Taal: Engels

Bron: Ministry of Health

Werkstoffen:

SEVOFLURANE

Beschikbaar vanaf:

ABBVIE BIOPHARMACEUTICALS LTD, ISRAEL

ATC-code:

N01AB08

farmaceutische vorm:

LIQUID FOR INHALATION

Samenstelling:

SEVOFLURANE 100 %

Toedieningsweg:

INHALATION

Prescription-type:

Required

Geproduceerd door:

ABBVIE LTD., UK

Therapeutisch gebied:

SEVOFLURANE

therapeutische indicaties:

Sevoflurane is indicated for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Autorisatie datum:

2022-08-31

Productkenmerken

COLORS:
Black
Dieline/Glued side
20073852
20073852
First page FRONT
SEVORANE
®
(sevoflurane 100%)
Liquid for inhalation
THERAPEUTIC INDICATIONS
Sevoflurane is indicated for induction and
maintenance of general anesthesia in adult
and pediatric patients for inpatient and
outpatient surgery.
DESCRIPTION
SEVORANE (sevoflurane), volatile liquid for
inhalation, a nonflammable and nonexplosive
liquid administered by vaporization, is
a halogenated general inhalation anesthetic
drug.
Sevoflurane
is
fluoromethyl
2,2,2,-trifluoro-1-(trifluoromethyl) ethyl ether
and its structural formula is:
Sevoflurane, Physical Constants are:
Molecular weight
200.05
Boiling point at
760 mm Hg
58.6°C
Specific gravity at
20°C
1.520 - 1.525
Vapor pressure in
mm Hg
157 mm Hg at 20°C
197 mm Hg at 25°C
317 mm Hg at 36°C
Distribution Partition Coefficients at 37°C:
Blood/Gas
0.63 - 0.69
Water/Gas
0.36
Olive Oil/Gas
47 – 54
Brain/Gas
1.15
Mean Component/Gas Partition
Coefficients at 25°C for Polymers Used
Commonly in Medical Applications:
Conductive rubber
14.0
Butyl rubber
7.7
Polyvinylchloride
17.4
Polyethylene
1.3
Sevoflurane is nonflammable and nonexplosive
as defined by the requirements of International
Electrotechnical Commission 601-2-13.
Sevoflurane is a clear, colorless, liquid
containing no additives. Sevoflurane is not
corrosive to stainless steel, brass, aluminum,
nickel-plated brass, chrome-plated brass or
copper beryllium. Sevoflurane is nonpungent.
It is miscible with ethanol, ether, chloroform,
and benzene, and it is slightly soluble in water.
Sevoflurane is stable when stored under
normal room lighting conditions according
to instructions. No discernible degradation
of sevoflurane occurs in the presence of
strong acids or heat. When in contact with
alkaline CO
2
absorbents (e.g., Baralyme
®
and to a lesser extent soda lime) within the
anesthesia machine, sevoflurane can undergo
degradation under certain conditions.
Degradation of sevoflurane is minimal,
and degradants are either undetectable or
present in non-toxic am