Nexgard Spectra 9mg2mg Chewable Tablets for Dogs 2-3.5kg

Land: Maleisië

Taal: Engels

Bron: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Werkstoffen:

AFOXOLANER; MILBEMYCIN OXIME

Beschikbaar vanaf:

Rhone Ma Malaysia Sdn Bhd

INN (Algemene Internationale Benaming):

AFOXOLANER; MILBEMYCIN OXIME

Eenheden in pakket:

3 Tablets; 6 Tablets

Geproduceerd door:

Boehringer Ingelheim Animal Health Do Brasil LTDA

Bijsluiter

Not applicable.
Information requested will be sent by the manufacturer (Merial)
directly to
BPFK.

Productkenmerken

NEXGARD SPECTRA 9 mg / 2 mg chewable tablets for dogs 2–3.5 kg
NEXGARD SPECTRA 19 mg / 4 mg chewable tablets for dogs >3.5–7.5 kg
NEXGARD SPECTRA 38 mg / 8 mg chewable tablets for dogs >7.5–15 kg
NEXGARD SPECTRA 75 mg / 15 mg chewable tablets for dogs >15–30 kg
NEXGARD SPECTRA 150 mg / 30 mg chewable tablets for dogs >30–60 kg
MANUFACTURED BY:
BOEHRINGER INGELHEIM ANIMAL HEALTH DO BRASIL LTDA, Fazenda Sao
Francisco CP 242, CEP 13140-970 Paulinia, Sao Paulo, Brazil
REGISTRATION HOLDER AND REPACKER:
RHONE MA MALAYSIA SDN BHD
(200001023279)
, Lot 18A & 18B, Jalan 241, Seksyen 51A, 46100 Petaling Jaya, Selangor
Tel : [phone] Fax : [phone] Email
:[e-mail]
COMPOSITION
Mottled red to reddish brown, circular shaped (tablets for dogs
2–3.5 kg) or rectangular shaped (tablets for dogs >3.5–7.5 kg,
tablets for dogs >7.5–15 kg, tablets for dogs
>15–30 kg and tablets for dogs >30–60 kg).
PHARMACODYNAMICS
Afoxolaner is an insecticide and acaricide of the isoxazoline family.
Afoxolaner acts as antagonist at ligand-gated chloride channels, in
particular those gated by the
neurotransmitter gamma-aminobutyric acid (GABA). Isoxazolines among
the chloride channel modulators, binds to a distinct and unique target
site within the insect
GABACIs, thereby blocking pre- and post- synaptic transfer of chloride
ions across cell membranes. Prolonged afoxolaner-induced
hyperexcitation results in
uncontrolled activity of the central nervous system and death of
insects and acarines. The selective toxicity of afoxolaner between
insects, acarines and mammals
may be inferred by the differential sensitivity of the insects and
acarines’s GABA receptors versus mammalian GABA receptors.
It is active against adult fleas as well as against several ticks
species such as
_Rhipicephalus sanguineus, Dermacentor reticulatus_
and
_D.variabilis, Ixodes ricinus_
and
_I.scapularis, Amblyomma americanum_
and
_Haemaphysalis longicornis_
. Afoxolaner kills fleas before egg production and therefore prevents
the ris