Land: Australië
Taal: Engels
Bron: Department of Health (Therapeutic Goods Administration)
fosinopril sodium,hydrochlorothiazide
Sun Pharma ANZ Pty Ltd
Fosinopril sodium,Hydrochlorothiazide
Registered
HYFORIL CMI V5 Oct 08 Page 1 of 13 HYFORIL ® 10/12.5 MG AND HYFORIL ® 20/12.5 MG _FOSINOPRIL + HYDROCHLOROTHIAZIDE TABLETS_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about HYFORIL 10/12.5 MG and HYFORIL 20/12.5 MG (fosinopril + hydrochlorothiazide tablets). It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking HYFORIL 10/12.5 MG or HYFORIL 20/12.5 MG against the benefits it is expected to have for you. IF YOU HAVE ANY CONCERNS ABOUT USING/TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. Keep this leaflet with this medicine. You may need to read it again. WHAT HYFORIL 10/12.5 MG AND HYFORIL 20/12.5 MG ARE USED FOR HYFORIL 10/12.5 MG and HYFORIL 20/12.5 MG contain two medicines, fosinopril sodium and hydrochlorothiazide. Both medicines reduce blood pressure, but work in different ways. Fosinopril belongs to the class of medicines called Angiotensin Converting Enzyme (ACE) inhibitors that act on the heart and blood vessels. Hydrochlorothiazide is a diuretic, i.e., it works by making your kidneys pass more water and salt. Together fosinopril and hydrochlorothiazide lower high blood pressure. Your doctor would have prescribed HYFORIL 10/12.5 MG or HYFORIL 20/12.5 MG (fosinopril + hydrochlorothiazide tablets) for the following: treatment of high blood pressure if treatment of high blood pressure is not satisfactory with fosinopril alone. Fosinopril and hydrochlorothiazide tablets are not suitable for initial therapy of high blood pressure. Your doctor may prescribe HYFORIL 10/12.5 MG or HYFORIL 20/12.5 MG for another reason. Ask your doctor if you have any questions about why HYFORIL 10/12.5 MG or HYFORIL 20/12.5 MG has been prescribed for you. HYFORIL CMI V5 Oct 08 Page 2 of 13 There is no evidence that HYFORIL 10/12.5 MG or HYFORIL 20/12.5 MG tablets are addictive. Fosinopril + hydrochlorothiazide may af Lees het volledige document
HYFORIL PI V4 Nov 2007 Page 1 of 15 HYFORIL 10/12.5 MG AND HYFORIL 20/12.5 MG (FOSINOPRIL 10 MG + HYDROCHLOROTHIAZIDE 12.5 MG & FOSINOPRIL 20 MG + HYDROCHLOROTHIAZIDE 12.5 MG) NAME OF THE MEDICINE FOSINOPRIL + HYDROCHLOROTHIAZIDE TABLETS 10 + 12.5 MG Each tablet contains: Fosinopril sodium 10 mg Hydrochlorothiazide Ph. Eur. 12.5 mg FOSINOPRIL + HYDROCHLOROTHIAZIDE TABLETS 20 + 12.5 MG Each tablet contains: Fosinopril sodium 20 mg Hydrochlorothiazide Ph. Eur. 12.5 mg FOSINOPRIL SODIUM STRUCTURE CAS number 88889-14-9 HYDROCHLOROTHIAZIDE STRUCTURE CAS Number: 58-93-5 HYFORIL PI V4 Nov 2007 Page 2 of 15 DESCRIPTION HYFORIL 10/12.5 MG and HYFORIL 20/12.5 MG Tablets contains contain Fosinopril sodium and hydrochlorothiazide. Fosinopril sodium is the ester prodrug of a long-acting angiotensin converting enzyme (ACE) inhibitor, fosinopril diacid. It is a sub-class of ACE inhibitors containing a phosphinate group which makes it different from other marketed ACE inhibitors. Fosinopril sodium is designated chemically as: _L_-proline, 4-cyclohexyl-1- [[[2-methyl-1- (1-oxopropoxy) propoxy] (4-phenylbutyl) phosphinyl]acetyl]-, sodium salt, _trans-_. The empiric formula of fosinopril sodium is C 30 H 45 NNaO 7 P. The molecular weight of fosinopril sodium is: 585.65. _Fosinopril sodium: _ Hydrochlorothiazide is the 3,4-dihydro derivative of chlorothiazide defined chemically as 6-chloro-3,4- dihydro-2_H_-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide. The empiric formula of hydrochlorothiazide is: C 7 H 8 CIN 3 O 4 S 2 and molecular Weight is: 297.72. _Hydrochlorothiazide: _ HYFORIL 10/12.5 MG and HYFORIL 20/12.5 MG contains the following inactive ingredients: Anhydrous Lactose, Crospovidone, Povidone, Microcrystalline Cellulose, Colloidal Anhydrous Silica, Purified Talc. PHARMACOLOGY PHARMACODYNAMICS _FOSINOPRIL SODIUM:_ ACE, a peptidyldipeptidase, catalyzes the conversion of the decapeptide angiotensin I to the octapeptide angiotensin II. Angiotensin II is a potent vasoconstrictor and it also stimulates aldosterone secretion Lees het volledige document