GLUCIENT XR EXTENDED-RELEASE TABLET 500MG

Land: Singapore

Taal: Engels

Bron: HSA (Health Sciences Authority)

Werkstoffen:

Metformin Hydrochloride

Beschikbaar vanaf:

GLORIOUS DEXA SINGAPORE PTE. LTD.

ATC-code:

A10BA02

farmaceutische vorm:

TABLET, EXTENDED RELEASE

Samenstelling:

Metformin Hydrochloride 500mg

Toedieningsweg:

ORAL

Prescription-type:

Prescription Only

Geproduceerd door:

PT. Ferron Par Pharmaceuticals

Autorisatie-status:

ACTIVE

Autorisatie datum:

2018-02-05

Productkenmerken

61231-02XX-YY
Last revised: dd/mm/yyyy
GLUCIENT XR
Extended-release tablet
GFR
(ML/MINUTE)
TOTAL MAXIMUM
DAILY DOSE
ADDITIONAL
CONSIDERATIONS
60-89
2000 mg
45-59
2000 mg
30-44
1000 mg
Dose
reduction
may
be
considered
in
relation to declining renal function.
Factors that may increase the risk of lactic
acidosis
(see
WARNINGS
AND
PRECAUTIONS) should be reviewed before
considering initiation of metformin.
The starting dose is at most half of the
maximum dose.
Metformin is contraindicated.
<30
-
COMPOSITIONS:
GLUCIENT XR 500
Each extended-release tablet contains
Metformin HCl 500 mg
GLUCIENT XR 750
Each extended-release tablet contains
Metformin HCl 750 mg
GLUCIENT XR 1000
Each extended-release tablet contains
Metformin HCl 1000 mg
LIST OF EXCIPIENTS:
GLUCIENT XR 500:
Carmellose sodium 2000, hypromellose 100M, purified water, colloidal
anhydrous silica, magnesium stearate.
GLUCIENT XR 750:
Carmellose sodium 2000, hypromellose 100M, purified water, colloidal
anhydrous silica, magnesium stearate.
GLUCIENT XR 1000:
Carmellose sodium 2000, hypromellose 100M, purified water, colloidal
anhydrous silica, magnesium stearate.
PRODUCT DESCRIPTIONS:
GLUCIENT XR 500:
White tablet, round shallow, diameter 12 mm, with marking “XR” on
one
side and without marking on the other side.
GLUCIENT XR 750:
White tablet, shallow convex, dimension 20 x 9 mm, with marking
“SR1” on
one side and without marking on the other side.
GLUCIENT XR 1000:
White tablet, shallow convex, dimension 22.25 x 9 mm, with marking
“SR2”
on one side and without marking on the other side.
PHARMACOLOGY:
ATC CODE: A10BA02
Metformin is a biguanide with antihyperglycemic effects, lowering both
basal and postprandial plasma glucose. It does not stimulate insulin
secretion and therefore does not produce hypoglycemia.
Mechanism of action, metformin may act via 3 mechanisms:
- reduction of hepatic glucose production by inhibiting
gluconeogenesis
and glycogenolysis,
- in muscle, by increasing insulin sensitivity, improving peripheral
glucose
uptake and utilizat