DERMASILKRX SDSPAK- triamcinolone acetonide cream, dimethicone cream kit

Land: Verenigde Staten

Taal: Engels

Bron: NLM (National Library of Medicine)

Werkstoffen:

TRIAMCINOLONE ACETONIDE (UNII: F446C597KA) (TRIAMCINOLONE ACETONIDE - UNII:F446C597KA)

Beschikbaar vanaf:

Patchwerx Labs, Inc.

INN (Algemene Internationale Benaming):

TRIAMCINOLONE ACETONIDE

Samenstelling:

TRIAMCINOLONE ACETONIDE 1 mg in 1 g

Prescription-type:

PRESCRIPTION DRUG

Autorisatie-status:

Abbreviated New Drug Application

Productkenmerken

DERMASILKRX SDSPAK- TRIAMCINOLONE ACETONIDE CREAM, DIMETHICONE CREAM
PATCHWERX LABS, INC.
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TRIAMCINOLONE ACETONIDE CREAM USP (0.1%)
DESCRIPTION
The topical corticosteroids constitute a class of primarily synthetic
steroids used as anti-inflammatory
and antipruritic agents. Triamcinolone acetonide is a member of this
class. Chemically triamcinolone
acetonide is pregna-1, 4-diene-3, 20-dione, 9-flouro-11,
21-dihydroxy-16, 17-[(1-
methylethylidene)bis(oxy)]-(11β16a). Its structural formula is:
Each gram of triamcinolone acetonide cream contains 1 mg triamcinolone
acetonide USP in a cream
base consisting of purified water, emulsifying wax, mineral oil,
propylene glycol, sorbitol solution,
cetyl palmitate, sorbic acid, and potassium sorbate.
CLINICAL PHARMACOLOGY
Topical corticosteroids share anti-inflammatory, antipruritic and
vasoconstrictive actions.
The mechanism of anti-inflammatory activity of the topical
corticosteroids is unclear. Various
laboratory methods, including vasoconstrictor assays, are used to
compare and predict potencies and/or
clinical efficacies of the topical corticosteroids. There is some
evidence to suggest that a
recognizable correlation exists between vasoconstrictor potency and
therapeutic efficacy in man.
_Pharmacokinetics_
The extent of percutaneous absorption of topical corticosteroids is
determined by many factors
including the vehicle, the integrity of the epidermal barrier, and the
use of occlusive dressings.
Topical corticosteroids can be absorbed from normal intact skin.
Inflammation and/or other disease
processes in the skin increase percutaneous absorption. Occlusive
dressings substantially increase the
percutaneous absorption of topical corticosteroids. Thus, occlusive
dressings may be a valuable
therapeutic adjunct for treatment of resistant dermatoses. (See DOSAGE
AND ADMINISTRATION).
Once absorbed through the skin, topical corticosteroids are handled
through pharmacokinetic pathways
similar to systemically administered corticosteroids. Corticosteroids
are bound to p