Land: Verenigde Staten
Taal: Engels
Bron: NLM (National Library of Medicine)
PYRIMETHAMINE (UNII: Z3614QOX8W) (PYRIMETHAMINE - UNII:Z3614QOX8W)
Amedra Pharmaceuticals LLC
PYRIMETHAMINE
PYRIMETHAMINE 25 mg
PRESCRIPTION DRUG
New Drug Application
DARAPRIM- PYRIMETHAMINE TABLET AMEDRA PHARMACEUTICALS LLC ---------- DARAPRIM (PYRIMETHAMINE) 25-MG SCORED TABLETS RX ONLY PRESCRIBING INFORMATION DESCRIPTION DARAPRIM (pyrimethamine) is an antiparasitic compound available in tablet form for oral administration. Each scored tablet contains 25 mg pyrimethamine and the inactive ingredients corn and potato starch, lactose, and magnesium stearate. Pyrimethamine, known chemically as 5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine, has the following structural formula: C H ClN Mol. Wt. 248.71 CLINICAL PHARMACOLOGY Pyrimethamine is well absorbed with peak levels occurring between 2 to 6 hours following administration. It is eliminated slowly and has a plasma half-life of approximately 96 hours. Pyrimethamine is 87% bound to human plasma proteins. MICROBIOLOGY: Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and _Toxoplasma gondii._ Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against _Toxoplasma gondii_ is greatly enhanced when used in conjunction with sulfonamides. This was demonstrated by Eyles and Coleman in the treatment of experimental toxoplasmosis in the mouse. Jacobs et al demonstrated that combination of the 2 drugs effectively prevented the development of severe uveitis in most rabbits following the inoculation of the anterior chamber of the eye with toxoplasma. INDICATIONS AND USAGE TREATMENT OF TOXOPLASMOSIS: DARAPRIM is indicated for the treatment of toxoplasmosis when used ® 12 13 4 1 2 conjointly with a sulfonamide, since synergism exists with this combination. TREATMENT OF ACUTE MALA Lees het volledige document