Land: Singapore
Taal: Engels
Bron: HSA (Health Sciences Authority)
CEFTIBUTEN
MSD PHARMA (SINGAPORE) PTE. LTD.
J01DD14
200 mg
CAPSULE
ORAL
Prescription Only
S.I.F.I. S.P.A.
1995-05-30
CCDS-MK3972-MTL-062014 Cedax® 200 mg Capsules Brand of Ceftibuten MSD FOR ORAL ADMINISTRATION DESCRIPTION: Ceftibuten dihydrate is a semisynthetic, third generation cephalosporin antibiotic for oral administration. Its chemical formula is: (+)-(6R, 7R)-7-[(z)-2-(2-amino-4- thiazolyl)-4-carboxycrotonamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, dihydrate. It occurs as both the cis- and trans-forms. Molecular weight = 446.43. Each CEDAX® Capsule contains 200 mg ceftibuten. The inactive ingredients in CEDAX® Capsules are microcrystalline cellulose, sodium starch glycolate and magnesium stearate. The gelatin capsule contains titanium dioxide as a coloring agent. ACTIONS: As with most beta-lactam antibiotics, the bactericidal activity of ceftibuten results from the inhibition of bacterial cell wall synthesis. Due to its chemical structure, ceftibuten is highly stable to beta-lactamases. Many beta-lactamase-producing microorganisms, which are resistant to penicillins or other cephalosporins, may be inhibited by ceftibuten. Ceftibuten-trans, formed by isomerization of ceftibuten (cis form), has only one-fourth to one- eighth the activity of ceftibuten. Microbiology: Ceftibuten is highly stable toward plasmid-mediated penicillinases and cephalosporinases. However, it is not stable to some cephalosporinases that are chromosomally mediated in organisms such as Citrobacter, Enterobacter and Bacteroides. As with other beta-lactam agents, ceftibuten should not be used against strains resistant to beta- lactams due to general mechanisms such as permeability or penicillin binding proteins (PBP) like penicillin-resistant S. pneumoniae. Ceftibuten binds preferentially to PBP-3 of E. coli, resulting in the formation of filamentous forms at 1/4 to 1/2 the minimum inhibitory conc Lees het volledige document