AVM-Artrisa 250mg Capsule

Land: Maleisië

Taal: Engels

Bron: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Werkstoffen:

Glucosamine Sulfate

Beschikbaar vanaf:

AV MANUFACTURING SDN.BHD

INN (Algemene Internationale Benaming):

Glucosamine Sulfate

Eenheden in pakket:

28 Capsule Capsules; 100 Capsule Capsules

Geproduceerd door:

AV MANUFACTURING SDN.BHD

Bijsluiter

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
AVM-ARTRISA
® 250MG CAPSULE
Glucosamine sulphate (250 mg)
1
WHAT IS IN THIS LEAFLET
1.
What AVM-Artrisa
®
250mg Capsule
is used for
2.
How AVM-Artrisa
®
250mg Capsule
Works
3.
Before you use AVM-Artrisa
®
250mg
Capsule
4.
How to use AVM-Artrisa
®
250mg
Capsule
5.
While you are using AVM-Artrisa
®
250mg Capsule
6.
Side effects
7.
Storage and disposal
8.
Product description
9.
Manufacturer and product registration
holder
10.
Date of revision
1.WHAT AVM-ARTRISA
® 250MG CAPSULE IS USED FOR
AVM-Artrisa
®
250mg Capsule is used to
relieve joint problems related to
osteoarthritis.
2.HOW AVM-ARTRISA
® 250MG CAPSULE
WORKS?
AVM-Artrisa
®
250mg Capsule contains
glucosamine which forms a key part of
cartilage (the cushioning substance between
bones in the joints). Glucosamine acts to
increase synovial fluid production, thereby
providing lubricant activity for proper joint
function.
3.BEFORE YOU USE AVM-ARTRISA
® 250MG
CAPSULE
_-When you must not use it_

If you are allergic to glucosamine or
any of the ingredients in the product.

If you are allergic to seafood.

Avoid use during the first 3 months of
pregnancy.
_-Before you start to use it_
Read the instruction and this leaflet
carefully to understand how this
medication should be taken.
Avoid use in children.
Tell your doctor or a pharmacist if you
have any medical conditions, especially
any of the following:

if you are pregnant, planning to become
pregnant, or breastfeeding.

if
you
have
allergies
to
seafood,
medicines
or
other
substances.
This
product contains glucosamine sulfate, a
seafood-derived
material.
It
is
not
recommended for people with seafood
allergies.

if you have high blood glucose

if you have severe liver and /or kidney
problems
_-Taking other medicines_
Talk to your doctor or a pharmacist if you
are taking:

any medicine for diabetes (to control
the blood sugar), such as metformin,
acarbose, repaglinide.

Warfarin (a blood-thinning drug).
Glucosamine may increase the

Productkenmerken

AVM-ARTRISA
® 250MG CAPSULE
AVM-ARTRISA
® 500MG CAPSULE
NAME AND STRENGTH OF ACTIVE SUBSTANCE
AVM-ARTRISA
® 250MG CAPSULE: Crystalline glucosamine sulphate sodium chloride 314mg
equivalent to 250 mg
glucosamine sulphate (derived from seafood)
AVM-ARTRISA
® 500MG CAPSULE: Crystalline glucosamine sulphate sodium chloride 628mg
equivalent to 500 mg
glucosamine sulphate (derived from seafood)
PRODUCT DESCRIPTION
AVM-ARTRISA
® 250MG CAPSULE: Hard gelatin bovine origin capsule, snap fit red/white
opaque capsule with
printed ‘ART 250’ at both side.
AVM-ARTRISA
® 500MG CAPSULE: Hard gelatin bovine origin capsule, snap fit red/white
opaque capsule with
printed ‘ART 500’ at both side
PHARMACODYNAMICS
Glucosamine is a natural substance found in chitin, mucoproteins, and
mucopolysaccharides. It is involved in the
manufacture of glycosaminoglycan, which forms cartilage tissue in the
body; glucosamine is also present in
tendons and ligaments. Glucosamine must be synthesised by the body but
the ability to do this declines with age.
Glucosamine and its salts have therefore been advocated in the
treatment of rheumatic disorders including
osteoarthritis.
Glucosamine also acts to improve the viscosity of synovial fluid by
increasing synovial fluid production,
thereby providing lubricant activity.
PHARMACOKINETICS
_Absorption _
After oral administration, bioavailability is low due to first-pass
hepatic metabolism~26%
The gastrointestinal absorption is close to 90%
_Distribution _
Glucosamine is not protein-bound, but rather incorporates into plasma
proteins (primarily globulins) , Volume of
Distribution: 2.5 Liters
_Metabolism _
-Liver, extensive
The first-pass effect in the liver in which more than 70% of
glucosamine is metabolized.
_Excretion _
Renal Excretion, 10%; feces, 11%
Part of a dose of glucosamine sulfate is eliminated as carbon dioxide
via expired air
INDICATION
Adjuvant therapy for osteoarthritis
RECOMMENDED DOSAGE
Adults
1500 milligrams daily, single dose or in 3 divided doses. Dosing also
may be based on