Land: Singapore
Taal: Engels
Bron: HSA (Health Sciences Authority)
Glimepiride
GLAXOSMITHKLINE PTE LTD
A10BD04
1mg
TABLET, FILM COATED
ORAL
Prescription Only
SmithKline Beecham Corporation d/b/a GlaxoSmithKine
2008-06-12
1 AVANDARYL™ ROSIGLITAZONE MALEATE-GLIMEPIRIDE QUALITATIVE AND QUANTITATIVE COMPOSITION _AVANDARYL_™ tablets contain two oral antidiabetic drugs used in the management of Type 2 diabetes: rosiglitazone (as maleate) and glimepiride. ROSIGLITAZONE Rosiglitazone is an oral antidiabetic agent which acts primarily by increasing insulin sensitivity. Rosiglitazone is used in the management of type 2 diabetes mellitus (also known as non-insulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes). Rosiglitazone improves glycaemic control while reducing circulating insulin levels. Pharmacological studies in animal models indicate that rosiglitazone improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. Rosiglitazone is not chemically or functionally related to the sulphonylureas, the biguanides, or the alpha-glucosidase inhibitors. Chemically, rosiglitazone is ( ±)-5-[[4-[2- (methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, (_Z_)-2- butenedioate (1:1), with a molecular weight of 473.52 (357.44 free base). The molecule has a single chiral centre and is present as a racemate. Due to rapid interconversion, the enantiomers are functionally indistinguishable. The structural formula is: The molecular formula is C 18 H 19 N 3 O 3 S •C 4 H 4 O 4 . Rosiglitazone is a white to off-white solid with a melting point range from 122 o to 123 o C. The pK a values of rosiglitazone are 6.8 and 6.1. It is readily soluble in ethanol and a buffered aqueous solution with pH of 2.3; solubility decreases with increasing pH in the physiological range. GLIMEPIRIDE Glimepiride is an oral antidiabetic drug of the sulphonylurea class. Glimepiride is a white to yellowish-white, crystalline, odourless to practically odourless powder. Chemically, glimepiride is 1-[[p-[2-(3-ethyl Lees het volledige document