Land: Canada
Taal: Engels
Bron: Health Canada
AMILORIDE HYDROCHLORIDE
ORBUS PHARMA INC
C03DB01
AMILORIDE
5MG
TABLET
AMILORIDE HYDROCHLORIDE 5MG
ORAL
100
Prescription
POTASSIUM-SPARING DIURETICS
Active ingredient group (AIG) number: 0113867001; AHFS:
CANCELLED (UNRETURNED ANNUAL)
2018-04-04
PRODUCT MONOGRAPH AMILORIDE HYDROCHLORIDE TABLETS, USP (amiloride hydrochloride tablets, USP) Tablets 5 mg Antikaliuretic Agent with Diuretic Properties ORBUS PHARMA INC. Date of Preparation: 20 Konrad Crescent August 09, 2004 MARKHAM, ONTARIO L6S 8T4 Date of Revision: Control #: 093182 1 PRODUCT MONOGRAPH NAME OF DRUG AMILORIDE HYDROCHLORIDE TABLETS, USP (amiloride hydrochloride tablets, USP) Tablets 5 mg THERAPEUTIC CLASSIFICATION Antikaliuretic Agent with Diuretic Properties ACTION AND CLINICAL PHARMACOLOGY Amiloride Hydrochloride Tablets, USP is an antikaliuretic drug with mild natriuretic diuretic and antihypertensive activity. These activities may be additive to the effects of thiazides or other saluretic-diuretic agents. The principal use of Amiloride Hydrochloride Tablets, USP is to conserve potassium in selected patients receiving kaliuretic-diuretic agents. Amiloride Hydrochloride Tablets, USP interferes with the mechanism involved in the exchange of sodium for potassium in the distal convoluted tubule and collecting duct of the nephron. An increase in sodium and a decrease in potassium and hydrogen ion excretion are induced in the presence or absence of aldosterone, thereby suggesting a direct tubular action of the drug. Chloride excretion may remain unchanged or increase slowly with continued therapy. Amiloride Hydrochloride Tablets, USP when administered with hydrochlorothiazide has been shown to result in less excretion of magnesium than thiazide or loop diuretics used alone. 2 Approximately 50% of an oral dose is absorbed. Amiloride Hydrochloride Tablets, USP usually begins to act within 2 hours after an oral dose. Its effect on electrolyte excretion reaches a peak between 6 and 10 hours and lasts about 24 hours. Peak plasma levels are obtained in 3 to 4 hours and plasma half-life varies from 6 to 9 hours. Amiloride hydrochloride is not metabolized by the liver. About 50% of a 20 mg dose of Amiloride Hydrochloride Tablets, USP is excreted unchanged in the urine and 40% is excreted in the stool with Lees het volledige document