Land: Taiwan
Taal: Chinees
Bron: 衛生福利部食品藥物管理署 (Ministry of Health and Welfare, Food And Drug Administration)
DIPYRIDAMOLE
裕利股份有限公司 台北市松山區南京東路四段126號10樓,10樓之1-3 (22853066)
B01AC07
錠劑
DIPYRIDAMOLE (2412400400) MG
鋁箔盒裝
製 劑
須由醫師處方使用
DELPHARM REIMS 10 RUE COLONEL CHARBONNEAUX, 51100 REIMS, FRANCE FR
dipyridamole
對於慢性狹心症之治療可能有效。
有效日期: 2027/02/20; 英文品名: Persantin 75mg Sugar-Coated Tablets
2012-02-20
Druckfarben Datum/Signatur KORREKTUR ERBETEN DRUCKFREIGABE Auftrags-Nr. 21/0 erstellt 10.03.21 WO Produktbezeichnung PERSANTIN 75MG SUGAR-COATED TABLETS TW Maße in mm 160 X 580 PACKAGE INFORM. PRXX Artikel-Nr. 312325GI-01 CODE 20 Druckfarben PANTONE BLACK C kleinste Schriftgröße 10 PT VORDERSEITE 312325GI-01 xxx PERSANTIN® 75 MG SUGAR-COATED TABLETS COMPOSITION [Active ingredient] Dipyridamole [Dosage form, strength] 1 sugar-coated tablet contains 2,6-bis(diethanolamino)-4,8-dipiperidino- pyrimido(5,4-d)- pyrimidine (= dipyridamole) 75 mg Excipients maize starch dried, starch soluble, calcium hydrogen phosphate anhydrous, colloidal silica anhydrous, magnesium stearate, talc, sucrose, macrogol 6000, acacia, yellow orange S, titanium dioxide, beeswax white, carnauba wax CLINICAL PHARMACOLOGY Dipyridamole inhibits the uptake of adenosine into erythrocytes, platelets and endothelial cells in vitro and in vivo; the inhibition amounts to 80% at its maximum and occurs dose-dependently at therapeutic concentrations (0.5 – 2 mcg/ml). Consequently,there is an increased concentration of adenosine locally to act on the platelet A2-receptor, stimulating platelet adenylate cyclase, thereby increasing platelet cAMP levels. Thus, platelet aggregation in response to various stimuli such as PAF, collagen and ADP is inhibited. Reduced platelet aggregation reduces platelet consumption towards normal levels. In addition, adenosine has a vasodilator effect and this is one of the mechanisms by which dipyridamole produces vasodilation. Following an I.V. does of dipyridamole tablet, the peak plasma concentration is reached about one hour. After I.V. administration, the beta phase has a half-life of approximately 40 minutes, and final terminal elimination phase has a half-life of about 13 hours. Protein binding of dipyridamole is about 97-99%. It is metabolized in liver, and the metabolites are mostly (about 95%) excreted via the bile into the feces. INDICATIONS May be effective on the treatment of chronic angina DOSAGE AND ADMINIST Lees het volledige document