Land: USA
Språk: engelsk
Kilde: NLM (National Library of Medicine)
CLINDAMYCIN HYDROCHLORIDE (UNII: T20OQ1YN1W) (CLINDAMYCIN - UNII:3U02EL437C)
MWI
CLINDAMYCIN HYDROCHLORIDE
CLINDAMYCIN 25 g in 1 mL
ORAL
PRESCRIPTION
INDICATIONS ZydaClin™ Oral Drops (for use in dogs and cats) are indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below: Dogs: Skin infections (wounds and abscesses) due to coagulase positive staphylococci (Staphylococcus aureus or Staphylococcus intermedius). Deep wounds and abscesses due to Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. Dental infections due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. Osteomyelitis due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. Cats: Skin infections (wounds and abscesses) due to Staphylococcus aureus, Staphylococcus intermedius, Streptococcus spp . Deep wounds and abscesses due to Clostridium perfringens and Bacteroides fragilis . Dental infections
HOW SUPPLIED ZydaClin™ Oral Drops is available as 20mL filled in 30 mL bottles (25 mg/mL) supplied in packers containing 12 cartoned bottles with direction labels and calibrated dosing droppers. To report a suspected adverse reaction or to request a Safety Data Sheet (MSDS) call 1-800-524-6332.
Abbreviated New Animal Drug Application
ZYDACLIN- CLINDAMYCIN SOLUTION/ DROPS MWI ---------- ZYDACLIN™ _(clindamycin)_ ORAL DROPS liquid FOR USE IN DOGS & CATS EQUIVALENT TO 25 MG PER ML CLINDAMYCIN NOT FOR USE IN HUMANS KEEP OUT OF REACH OF CHILDREN CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. ANADA 200-538, Approved by FDA DESCRIPTION ZydaClin™ Oral Drops contain clindamycin hydrochloride which is the hydrate salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chlorosubstitution of the 7(R)-hydroxly group of a naturally produced antibiotic produced by _Streptomyces lincolnensis var. lincolnensis._ ZydaClin™ Oral Drops ( For Use in Dogs and Cats) is a palatable formulation intended for oral administration. Each mL of ZydaClin™ Oral Drops liquid contains clindamycin hydrochloride equivalent to 25 mg clindamycin; and ethyl alcohol, 8.64%. ACTION SITE AND MODE OF ACTION: Clindamycin is an inhibitor of protein synthesis in the bacterial cell. The site of binding appears to be in the 50S sub-unit of the ribosome. Binding occurs to the soluble RNA fraction of certain ribosomes, thereby inhibiting the binding of amino acids to those ribosomes. Clindamycin differs from cell wall inhibitors in that it causes irreversible modification of the protein- synthesizing subcellular elements at the ribosomal level. MICROBIOLOGY Clindamycin is a lincosaminide antimicrobial agent with activity against the wide variety of aerobic and anaerobic bacterial pathogens. Clindamycin is a bacteriostatic compound that inhibits bacterial protein synthesis by binding to 50S ribosomal sub-unit. The minimum inhibitor concentrations (MICs) of Gram- positive and obligate anaerobic pathogens isolated from dogs and cats in the United States are presented in the Table 1 and Table 2. Bacteria were isolated in 1998-1999. All MICs were performed in accordance with the National committee for Clinical Standards (NCCLS). PHARMACOLOGY ABSORPTION: Clindamycin hydrochloride is rapidly absorbed from the canine an read_full_document