Tolazine Injection

Land: Australia

Språk: engelsk

Kilde: APVMA (Australian Pesticides and Veterinary Medicines Authority)

Aktiv ingrediens:

TOLAZOLINE AS TOLAZOLINE HYDROCHLORIDE

Tilgjengelig fra:

AKORN ANIMAL HEALTH INC

Legemiddelform:

PARENTERAL LIQUID/SOLUTION/SUSPENSION

Sammensetning:

TOLAZOLINE AS TOLAZOLINE HYDROCHLORIDE IMIDAZOLE Active 100.0 mg/ml

Enheter i pakken:

100 mL

Klasse:

VM - Veterinary Medicine

Terapeutisk område:

ANTIDOTES

Produkt oppsummering:

Poison schedule: 4; Withholding period: MEAT WITHHOLDING PERIOD (HORSES): DO NOT USE less than 28 days before slaughter for human consumption.; Host/pest details: HORSE: [REVERSAL OF XYLAZINE BASED SEDATION]

Autorisasjon status:

Stopped

Autorisasjon dato:

2023-07-01

Informasjon til brukeren

Product Name:
APVMA Approval No:
Tolazine Injection
90680/129763
Label Name:
Tolazine Injection
Signal Headings:
PRESCRIPTION ANIMAL REMEDY
KEEP OUT OF REACH OF CHILDREN
FOR ANIMAL TREATMENT ONLY
Constituent
Statements:
Tolazoline 100 mg/mL (as Tolazoline hydrochloride)
Claims:
Xylazine Reversing Agent and Antagonist for Use in Horses
Tolazoline should be used in horses when it is desirable to reverse
the effects of sedation
and analgesia caused by xylazine.
Net Contents:
100 mL
Directions for Use:
Restraints:
Contraindications:
Precautions:
The safety of Tolazoline in pregnant mares or in horses intended for
breeding has not been
established.
This drug should be administered with greater care to animals
exhibiting signs of stress,
debilitation, cardiac disease, sympathetic blockade, hypovolemia or
shock. The safety of
this drug has not been evaluated in horses with metabolically unstable
conditions. This
drug should be administered with extreme care to horses that are
exhibiting any type of
circulatory compromise, particularly that associated with blood loss.
In general, all drugs, including Tolazine, when given intravenously,
should be administered
carefully and at a slow rate to allow venous dilution to occur prior
to the drug reaching the
brain and heart. RLP APPROVED
The drug reverses the analgesic effects of xylazine as well as the
sedative effects. If the
animal was given xylazine for its analgesic properties, reversal may
result in return of
normal pain perception.
The use of Tolazine has not been evaluated for reversing xylazine used
as a
preanaesthetic to a general anaesthetic.
Side Effects:
Temporary side effects of tolazoline may be tachycardia; peripheral
vasodilation, evidenced
by bright pink to dark red mucous membranes of the gingiva and
conjunctiva; and
hyperalgesia of the lips, evidenced by licking or flipping of the lips
even before the injection
is completed. Some horses may exhibit piloerection, especially in the
rump and neck
regions, 4 to 12 minutes after dosing. Clear lachrymal and nasal
d