SIMPARICA TRIO- sarolaner, moxidectin, and pyrantel tablet, chewable

Land: USA

Språk: engelsk

Kilde: NLM (National Library of Medicine)

Aktiv ingrediens:

SAROLANER (UNII: DM113FTW7F) (SAROLANER - UNII:DM113FTW7F), MOXIDECTIN (UNII: NGU5H31YO9) (MOXIDECTIN - UNII:NGU5H31YO9), PYRANTEL PAMOATE (UNII: 81BK194Z5M) (PYRANTEL - UNII:4QIH0N49E7)

Tilgjengelig fra:

Zoetis Inc.

Administreringsrute:

ORAL

Resept typen:

PRESCRIPTION

Indikasjoner:

SIMPARICA TRIO is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina ) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala ) infections. SIMPARICA TRIO kills adult fleas (Ctenocephalides felis ) and is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (blacklegged tick), and Rhipicephalus sanguineus (brown dog tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. SIMPARICA TRIO is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks. There are no known contraindications for the use of SIMPARICA TRIO.

Produkt oppsummering:

SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is available in six flavored tablet sizes (see DOSAGE AND ADMINISTRATION ). Each tablet size is available in packages of one, three, or six tablets.

Autorisasjon status:

New Animal Drug Application

Preparatomtale

SIMPARICA TRIO- SAROLANER, MOXIDECTIN, AND PYRANTEL TABLET, CHEWABLE
ZOETIS INC.
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_SIMPARICA TRIO_
_SIMPARICA TRIO_
_(SAROLANER, MOXIDECTIN, AND PYRANTEL CHEWABLE TABLETS)_
FOR ORAL USE IN DOGS ONLY
CAUTION
Federal (USA) law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets)
is a flavored,
chewable tablet for administration to dogs 8 weeks of age and older.
Each tablet is
formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg)
sarolaner, 0.011
mg/lb (24 μg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as
pamoate salt).
Sarolaner is a member of the isoxazoline class of parasiticides and
the chemical name is
1‑(5’-((5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-
3’-H-spiro(azetidine-3,1’-(2)benzofuran)-1-yl)-2-(methylsulfonyl)ethanone.
SIMPARICA
TRIO contains the S-enantiomer of sarolaner.
Moxidectin is a semi-synthetic methoxime derivative of nemadectin
which is a
fermentation product of Streptomyces cyaneogriseus subspecies
noncyanogenus.
Moxidectin is a pentacyclic 16-membered lactone macrolide. The
chemical name for
moxidectin is
(6R,23E,25S)-5-O-Demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-
6,28-epoxy-23-(methoxyimino)milbemycin B.
Pyrantel belongs to a family classified chemically as
tetrahydropyrimidines and the
chemical name is (E)‑1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl)
vinyl] pyrimidine 4,4’
methylenebis [3-hydroxy-2-naphthoate] (1:1). It is a yellow,
water-insoluble crystalline
salt of the tetrahydropyrimidine base and pamoic acid containing 34.7%
base activity.
INDICATIONS
SIMPARICA TRIO is indicated for the prevention of heartworm disease
caused by
_Dirofilaria immitis_ and for the treatment and control of roundworm
(immature adult and
adult _Toxocara canis_ and adult _Toxascaris leonina_) and hookworm
(L4, immature adult,
and adult_ Ancylostoma caninum _and adult _Uncinaria stenocephala_)
infections.
SIMPARICA TRIO