USA - engelsk - NLM (National Library of Medicine)

apotex corp. - penicillamine (unii: gnn1dv99gx) (penicillamine - unii:gnn1dv99gx) - penicillamine capsules  are indicated in the treatment of wilson's disease, cystinuria, and in patients with severe, active rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy. available evidence suggests that penicillamine capsules are not of value in ankylosing spondylitis.   wilson’s disease — wilson’s disease (hepatolenticular degeneration) occurs in individuals who have inherited an autosomal recessive defect that leads to an accumulation of copper far in excess of metabolic requirements. the excess copper is deposited in several organs and tissues, and eventually produces pathological effects primarily in the liver, where damage progresses to postnecrotic cirrhosis, and in the brain, where degeneration is widespread. copper is also deposited as characteristic, asymptomatic, golden-brown kayser-fleischer rings in the corneas of all patients with cerebral symptomatology and some patients who are either asymptomatic or manifest only hepatic symptomatology.   two types of patients require treatment for wilson's disease: (1) the symptomatic, and (2) the asymptomatic in whom it can be assumed the disease will develop in the future if the patient is not treated.   the diagnosis, if suspected on the basis of family or individual history or physical examination, can be confirmed if the plasma copper-protein ceruloplasmin** is <20 mg/dl and either a quantitative determination in a liver biopsy specimen shows an abnormally high concentration of copper (>250 mcg/g dry weight) or kayser- fleischer rings are present.   treatment has two objectives: (1) to minimize dietary intake of copper; (2) to promote excretion and complex formation (i.e., detoxification) of excess tissue copper.   the first objective is attained by a daily diet that contains no more than one or two milligrams of copper. such a diet should exclude, most importantly, chocolate, nuts, shellfish, mushrooms, liver, molasses, broccoli, and cereals and dietary supplements enriched with copper, and be composed to as great an extent as possible of foods with a low copper content. distilled or demineralized water should be used if the patient's drinking water contains more than 0.1 mg of copper per liter. 1 for the second objective, a copper chelating agent is used.   in symptomatic patients this treatment usually produces marked neurologic improvement, fading of kayser- fleischer rings, and gradual amelioration of hepatic dysfunction and psychic disturbances.   clinical experience to date suggests that life is prolonged with the above regimen. noticeable improvement may not occur for one to three months. occasionally, neurologic symptoms become worse during initiation of therapy with penicillamine capsules. despite this, the drug should not be withdrawn. temporary interruption carries an increased risk of developing a sensitivity reaction upon resumption of therapy, although it may result in clinical improvement of neurological symptoms (see warnings). if the neurological symptoms and signs continue to worsen for a month after the initiation of penicillamine capsules therapy, several short courses of treatment with 2,3 - dimercaprol (bal) while continuing penicillamine capsules may be considered.   treatment of asymptomatic patients has been carried out for over thirty years. symptoms and signs of the disease appear to be prevented indefinitely if daily treatment with penicillamine capsules is continued.   cystinuria — cystinuria is characterized by excessive urinary excretion of the dibasic amino acids, arginine, lysine, ornithine, and cystine, and the mixed disulfide of cysteine and homocysteine. the metabolic defect that leads to cystinuria is inherited as an autosomal, recessive trait. metabolism of the affected amino acids is influenced by at least two abnormal factors: (1) defective gastrointestinal absorption and (2) renal tubular dysfunction.   arginine, lysine, ornithine, and cysteine are soluble substances, readily excreted. there is no apparent pathology connected with their excretion in excessive quantities.   cystine, however, is so slightly soluble at the usual range of urinary ph that it is not excreted readily, and so crystallizes and forms stones in the urinary tract. stone formation is the only known pathology in cystinuria.   normal daily output of cystine is 40 mg to 80 mg. in cystinuria, output is greatly increased and may exceed 1 g/day. at 500 to 600 mg/day, stone formation is almost certain. when it is more than 300 mg/day, treatment is indicated.   conventional treatment is directed at keeping urinary cystine diluted enough to prevent stone formation, keeping the urine alkaline enough to dissolve as much cystine as possible, and minimizing cystine production by a diet low in methionine (the major dietary precursor of cystine). patients must drink enough fluid to keep urine specific gravity below 1.010, take enough alkali to keep urinary ph at 7.5 to 8, and maintain a diet low in methionine. this diet is not recommended in growing children and probably is contraindicated in pregnancy because of its low protein content (see precautions).   when these measures are inadequate to control recurrent stone formation, penicillamine capsules  may be used as additional therapy, and when patients refuse to adhere to conventional treatment, penicillamine capsules  may be a useful substitute. it is capable of keeping cystine excretion to near normal values, thereby hindering stone formation and the serious consequences of pyelonephritis and impaired renal function that develop in some patients.   bartter and colleagues depict the process by which penicillamine interacts with cystine to form penicillamine cysteine mixed disulfide as: in this process, it is assumed that the deprotonated form of penicillamine, ps', is the active factor in bringing about the disulfide interchange.   rheumatoid arthritis — because penicillamine capsules can cause severe adverse reactions, its use in rheumatoid arthritis should be restricted to patients who have severe, active disease and who have failed to respond to an adequate trial of conventional therapy. even then, benefit-to-risk ratio should be carefully considered. other measures, such as rest, physiotherapy, salicylates, and corticosteroids should be used, when indicated, in conjunction with penicillamine capsules (see precautions). except for the treatment of wilson's disease or certain patients with cystinuria, use of penicillamine during pregnancy is contraindicated (see warnings).   although breast milk studies have not been reported in animals or humans, mothers on therapy with penicillamine should not nurse their infants.   patients with a history of penicillamine-related aplastic anemia or agranulocytosis should not be restarted on penicillamine (see warnings and adverse reactions).   because of its potential for causing renal damage, penicillamine should not be administered to rheumatoid arthritis patients with a history or other evidence of renal insufficiency.

USA - engelsk - NLM (National Library of Medicine)

actavis pharma, inc. - penicillamine (unii: gnn1dv99gx) (penicillamine - unii:gnn1dv99gx) - penicillamine capsules are indicated in the treatment of wilson's disease, cystinuria, and in patients with severe, active rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy. available evidence suggests that penicillamine capsules are not of value in ankylosing spondylitis. wilson’s disease (hepatolenticular degeneration) occurs in individuals who have inherited an autosomal recessive defect that leads to an accumulation of copper far in excess of metabolic requirements. the excess copper is deposited in several organs and tissues, and eventually produces pathological effects primarily in the liver, where damage progresses to postnecrotic cirrhosis, and in the brain, where degeneration is widespread. copper is also deposited as characteristic, asymptomatic, golden-brown kayser-fleischer rings in the corneas of all patients with cerebral symptomatology and some patients who are either asymptomatic or manifest only hepatic symptomatology. two types of patients require t

USA - engelsk - NLM (National Library of Medicine)

bryant ranch prepack - penicillamine (unii: gnn1dv99gx) (penicillamine - unii:gnn1dv99gx) - penicillamine capsules are indicated in the treatment of wilson's disease, cystinuria, and in patients with severe, active rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy. available evidence suggests that penicillamine capsules are not of value in ankylosing spondylitis.   wilson’s disease — wilson’s disease (hepatolenticular degeneration) occurs in individuals who have inherited an autosomal recessive defect that leads to an accumulation of copper far in excess of metabolic requirements. the excess copper is deposited in several organs and tissues, and eventually produces pathological effects primarily in the liver, where damage progresses to postnecrotic cirrhosis, and in the brain, where degeneration is widespread. copper is also deposited as characteristic, asymptomatic, golden-brown kayser-fleischer rings in the corneas of all patients with cerebral symptomatology and some patients who are either asymptomatic or manifest only hepatic symptomatology.   two typ

USA - engelsk - NLM (National Library of Medicine)

ani pharmaceuticals, inc. - penicillamine (unii: gnn1dv99gx) (penicillamine - unii:gnn1dv99gx) - penicillamine capsules are indicated in the treatment of wilson’s disease, cystinuria, and in patients with severe, active rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy. available evidence suggests that penicillamine capsules are not of value in ankylosing spondylitis. wilson’s disease - wilson’s disease (hepatolenticular degeneration) occurs in individuals who have inherited an autosomal recessive defect that leads to an accumulation of copper far in excess of metabolic requirements. the excess copper is deposited in several organs and tissues, and eventually produces pathological effects primarily in the liver, where damage progresses to postnecrotic cirrhosis, and in the brain, where degeneration is widespread. copper is also deposited as characteristic, asymptomatic, golden-brown kayser-fleischer rings in the corneas of all patients with cerebral symptomatology and some patients who are either asymptomatic or manifest only hepatic symptomatology. two types o

USA - engelsk - NLM (National Library of Medicine)

oceanside pharmaceuticals - penicillamine (unii: gnn1dv99gx) (penicillamine - unii:gnn1dv99gx) - penicillamine capsules are indicated in the treatment of wilson's disease, cystinuria, and in patients with severe, active rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy. available evidence suggests that penicillamine capsules are not of value in ankylosing spondylitis. wilson’s disease (hepatolenticular degeneration) occurs in individuals who have inherited an autosomal-recessive defect that leads to an accumulation of copper far in excess of metabolic requirements. the excess copper is deposited in several organs and tissues, and eventually produces pathological effects primarily in the liver, where damage progresses to postnecrotic cirrhosis, and in the brain, where degeneration is widespread. copper is also deposited as characteristic, asymptomatic, golden-brown kayser-fleischer rings in the corneas of all patients with cerebral symptomatology and some patients who are either asymptomatic or manifest only hepatic symptomatology. two types of patients require t

USA - engelsk - NLM (National Library of Medicine)

par pharmaceutical, inc. - penicillamine (unii: gnn1dv99gx) (penicillamine - unii:gnn1dv99gx) - penicillamine tablets are indicated in the treatment of wilson’s disease, cystinuria, and in patients with severe, active rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy. available evidence suggests that penicillamine tablets are not of value in ankylosing spondylitis. wilson’s disease  - wilson’s disease (hepatolenticular degeneration) results from the interaction of an inherited defect and an abnormality in copper metabolism. the metabolic defect, which is the consequence of the autosomal inheritance of one abnormal gene from each parent, manifests itself in a greater positive copper balance than normal. as a result, copper is deposited in several organs and appears eventually to produce pathologic effects most prominently seen in the brain, where degeneration is widespread; in the liver, where fatty infiltration, inflammation, and hepatocellular damage progress to postnecrotic cirrhosis; in the kidney, where tubular and glomerular dysfunction results; and in the

USA - engelsk - NLM (National Library of Medicine)

par pharmaceutical, inc. - penicillamine (unii: gnn1dv99gx) (penicillamine - unii:gnn1dv99gx) - penicillamine capsules are indicated in the treatment of wilson's disease, cystinuria, and in patients with severe, active rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy. available evidence suggests that penicillamine capsules are not of value in ankylosing spondylitis. w il son’s  disease —   wilson’s  disease  (hepatolenticular  degeneration)  occurs  in  individuals  who  have inherited an autosomal recessive defect that leads to an accumulation of copper far in excess of metabolic requirements. the excess copper is deposited in several organs and tissues, and eventually produces pathological effects primarily in the liver, where damage progresses to postnecrotic cirrhosis, and in the brain, where degeneration is widespread. copper is also deposited as characteristic, asymptomatic, golden-brown kayser-fleischer rings in the corneas of all patients with cerebral symptomatology and some patients who are either asymptomatic or manifest only hepatic symptomatology.

USA - engelsk - NLM (National Library of Medicine)

dr. reddy's laboratories inc. - penicillamine (unii: gnn1dv99gx) (penicillamine - unii:gnn1dv99gx) - penicillamine capsules are indicated in the treatment of wilson's disease, cystinuria, and in patients with severe, active rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy. available evidence suggests that penicillamine capsules are not of value in ankylosing spondylitis. wilson’s disease — wilson’s disease (hepatolenticular degeneration) occurs in individuals who have inherited an autosomal recessive defect that leads to an accumulation of copper far in excess of metabolic requirements. the excess copper is deposited in several organs and tissues, and eventually produces pathological effects primarily in the liver, where damage progresses to postnecrotic cirrhosis, and in the brain, where degeneration is widespread. copper is also deposited as characteristic, asymptomatic, golden-brown kayser-fleischer rings in the corneas of all patients with cerebral symptomatology and some patients who are either asymptomatic or manifest only hepatic symptomatology. two types of

USA - engelsk - NLM (National Library of Medicine)

granules pharmaceuticals inc. - penicillamine (unii: gnn1dv99gx) (penicillamine - unii:gnn1dv99gx) - penicillamine capsules are indicated in the treatment of wilson's disease, cystinuria, and in patients with severe, active rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy. available evidence suggests that penicillamine capsules are not of value in ankylosing spondylitis. wilson’s disease — wilson’s disease (hepatolenticular degeneration) occurs in individuals who have inherited an autosomal recessive defect that leads to an accumulation of copper far in excess of metabolic requirements. the excess copper is deposited in several organs and tissues, and eventually produces pathological effects primarily in the liver, where damage progresses to postnecrotic cirrhosis, and in the brain, where degeneration is widespread. copper is also deposited as characteristic, asymptomatic, golden-brown kayser-fleischer rings in the corneas of all patients with cerebral symptomatology and some patients who are either asymptomatic or manifest only hepatic symptomatology. two types o

USA - engelsk - NLM (National Library of Medicine)

lupin pharmaceuticals, inc. - penicillamine (unii: gnn1dv99gx) (penicillamine - unii:gnn1dv99gx) - penicillamine tablets are indicated in the treatment of wilson's disease, cystinuria, and in patients with severe, active rheumatoid arthritis who have failed to respond to an adequate trial of conventional therapy. available evidence suggests that penicillamine tablets are not of value in ankylosing spondylitis. wilson's disease (hepatolenticular degeneration) results from the interaction of an inherited defect and an abnormality in copper metabolism. the metabolic defect, which is the consequence of the autosomal inheritance of one abnormal gene from each parent, manifests itself in a greater positive copper balance than normal. as a result, copper is deposited in several organs and appears eventually to produce pathologic effects most prominently seen in the brain, where degeneration is widespread; in the liver, where fatty infiltration, inflammation, and hepatocellular damage progress to postnecrotic cirrhosis; in the kidney, where tubular and glomerular dysfunction results; and in the eye, where characte