PHYSOSTIGMINE SALICYLATE injection

Land: USA

Språk: engelsk

Kilde: NLM (National Library of Medicine)

Aktiv ingrediens:

PHYSOSTIGMINE SALICYLATE (UNII: 2046ZRO9VU) (PHYSOSTIGMINE - UNII:9U1VM840SP)

Tilgjengelig fra:

Medical Purchasing Solutions, LLC

Administreringsrute:

INTRAVENOUS

Resept typen:

PRESCRIPTION DRUG

Indikasjoner:

To reverse the effect upon the central nervous system, caused by clinical or toxic dosages of drugs capable of producing the anticholinergic syndrome. Physostigmine Salicylate Injection should not be used in the presence of asthma, gangrene, diabetes, cardiovascular disease, mechanical obstruction of the intestine or urogenital tract or any vagotonic state, and in patients receiving choline esters and depolarizing neuromuscular blocking agents (decamethonium, succinylcholine). For post-anesthesia, the concomitant use of atropine with physostigmine salicylate is not recommended, since the atropine antagonizes the action of physostigmine. 2.0 mg intramuscularly or INTRAVENOUSLY AT SLOW CONTROLLED RATE (SEE ABOVE). Dosage may be repeated if life threatening signs, such as arrhythmia, convulsions or coma occurs.

Produkt oppsummering:

NDC 17478-510-02 2 mL Ampules packed 10 per box, 1 mg per mL. STORAGE: Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. SOME DRUGS WHICH PRODUCE THE ANTICHOLINERGIC SYNDROME Amitriptyline, Amoxapine, Anisotropine, Atropine, Benztropine, Biperiden, Carbinoxamine, Clidinium, Cyclobenzaprine, Desipramine, Doxepin, Homatropine, Hyoscine, Hyoscyamine, Hyoscyamus, Imipramine, Lorazepam, Maprotiline, Mepenzolate, Nortriptyline, Propantheline, Protriptyline, Scopolamine, Trimipramine. SOME PLANTS THAT PRODUCE THE ANTICHOLINERGIC SYNDROME Black Henbane, Deadly Night Shade, Devil's Apple, Jimson Weed, Loco Seeds or Weeds, Matrimony Vine, Night Blooming Jessamine, Stinkweed. Akorn Manufactured by: Akorn, Inc. Lake Forest, IL 60045 PS00N Rev. 06/16

Autorisasjon status:

unapproved drug other

Preparatomtale

PHYSOSTIGMINE SALICYLATE- PHYSOSTIGMINE SALICYLATE INJECTION
MEDICAL PURCHASING SOLUTIONS, LLC
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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PHYSOSTIGMINE SALICYLATE INJECTION
RX ONLY
DESCRIPTION:
Physostigmine Salicylate Injection is a derivative of the Calabar
bean, and its active moiety,
physostigmine, is also known as eserine. Its chemical structure is:
It is soluble in water and a 0.5% aqueous solution has a pH of 5.8.
Physostigmine Salicylate Injection is available in 2 mL ampules, each
mL containing 1 mg of
Physostigmine Salicylate in a vehicle composed of sodium metabisulfite
0.1%, benzyl alcohol 2.0% as
a preservative in Water for Injection.
CLINICAL PHARMACOLOGY:
Physostigmine Salicylate Injection is a reversible anticholinesterase
which effectively increases the
concentration of acetylcholine at the sites of cholinergic
transmission. The action of acetylcholine is
normally very transient because of its hydrolysis by the enzyme,
acetylcholinesterase. Physostigmine
Salicylate Injection inhibits the destructive action of
acetylcholinesterase and thereby prolongs and
exaggerates the effect of the acetylcholine.
Physostigmine Salicylate Injection contains a tertiary amine and
easily penetrates the blood brain barrier,
while an anticholinesterase, such as neostigmine, which has a
quaternary ammonium ion is not capable
of crossing the barrier. Physostigmine Salicylate Injection can
reverse both central and peripheral
anticholinergia. The anticholinergic syndrome has both central and
peripheral signs and symptoms.
Central toxic effects include anxiety, delirium, disorientation,
hallucinations, hyperactivity and seizures.
Severe poisoning may produce coma, medullary paralysis and death.
Peripheral toxicity is characterized
by tachycardia, hyperpyrexia, mydriasis, vasodilation, urinary
retention, diminution of gastrointestinal
motility, decrease of secretion in sa