Lariam

Land: Australia

Språk: engelsk

Kilde: Department of Health (Therapeutic Goods Administration)

Aktiv ingrediens:

Mefloquine hydrochloride

Tilgjengelig fra:

Roche Products Pty Ltd

Klasse:

Medicine Registered

Informasjon til brukeren

LARIAM
®

_contains the active ingredient mefloquine_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about LARIAM tablets.
It does not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking LARIAM
tablets against the benefits expected
for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT LARIAM IS USED
FOR
LARIAM is used to prevent and treat
malaria.
LARIAM contains the active
ingredient mefloquine. LARIAM
belongs to a group of medicines
called quinolones (pronounced kwin-
o-lones).
LARIAM works by killing the
parasites that may cause or have
caused malaria.
_WHERE AND HOW YOU CAN_
_CONTRACT MALARIA_
Malaria is an infectious disease that
is widespread in tropical and
subtropical areas of Africa, Latin
America, Asia and countries around
the Pacific. There are different forms
of malaria, each of them caused by a
specific parasite transmitted to
humans by the bite of the Anopheles
mosquito.
_PRECAUTIONS AGAINST MALARIA_
The best protection against malaria is
to avoid mosquito bites. The
mosquito that causes malaria mainly
bites between dusk and dawn.
Therefore the following
precautionary measures are
recommended:
•
during this period, wear light-
coloured clothing that covers as
much of your skin as possible
•
apply mosquito repellent to your
uncovered skin and to your
clothes
•
when sleeping in rooms that are
not protected against mosquitoes,
use an effective mosquito net well
tucked under the mattress
•
additional protection is provided
by smoke spirals, insect sprays
and candles.
_SYMPTOMS OF MALARIA_
The symptoms of malaria may often
be mild. However, malaria should be
suspected if, after one week in a
malarial area, you suffer unexplained
fever with or without other
symptoms such as headache,

Preparatomtale

Lariam

 PI 130802 

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1 of 14 
CDS 4.0 

1
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NAME OF THE MEDICINE 
LARIAM
®

MEFLOQUINE HYDROCHLORIDE 
Chemical name: _dl-erythro-alpha-2-piperidy-2,8-bis(trifluoromethyl)-4-quinoline methanol  _
OH
 N
 N
 H 
 H
 H 
 CF
CF
 3
   3

MW: 414.78 
CAS registry number: 51773-92-3 

DESCRIPTION 

Mefloquine is an odourless, bitter-tasting, white crystalline powder.  It is soluble in methanol 
and ethanol but practically insoluble in water.  A 1% aqueous suspension has a pH of 5.6. 

LARIAM tablets are cylindrical biplanar, white to off-white, cross-scored with break bars on 
both faces and marked with "RO", "C", "HE" and an imprinted hexagon in the quadrants of 
one face.  They contain 250 mg mefloquine in the form of mefloquine hydrochloride (274.09 
mg).  LARIAM tablets also contain the following excipients: poloxamer 3800, 
microcrystalline cellulose, lactose, maize starch, crospovidone, ammonium calcium alginate, 
talc and magnesium stearate. 

LARIAM (mefloquine) is an antimalarial belonging to the quinoline-methanol group of 
medicines and is structurally related to quinine.  

PHARMACOLOGY 
_PHARMACODYNAMICS _
The effectiveness in the treatment of malaria is due essentially to destruction of the asexual 
intraerythrocytic forms of the human malarial parasites: _Plasmodium falciparum, P. vivax, P. _
_malariae and P. ovale_. However data concerning the treatment of _P.malariae_ and _P.ovale_ 
were limited. 

It is also effective against _P. falciparum_ infections resistant to other antimalarials such as 
chloroquine and other 4-amino-quinoline derivatives, proguanil, pyrimethamine and 
pyrimethamine-sulfonamide combinations. 

Laboratory animal studies have shown that resistance to mefloquine can be readily induced in 
the malarial