FUROSEMIDE AN furosemide (frusemide) 20 mg tablet bottle

Land: Australia

Språk: engelsk

Kilde: Department of Health (Therapeutic Goods Administration)

Aktiv ingrediens:

furosemide (frusemide)

Tilgjengelig fra:

Amneal Pharma Australia Pty Ltd

INN (International Name):

furosemide (frusemide)

Autorisasjon status:

Registered

Informasjon til brukeren

_Furosemide AN tablets – Consumer Medicine Information _
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_Furosemide AN CMI v3.0 _
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_Page 1 _
FUROSEMIDE AN TABLETS
_Furosemide (frusemide) _
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This
leaflet
answers
some
common
questions
about
Furosemide
AN.
It
does
not
contain
all
the
available
information.
It
does
not
take
the
place
of
talking
to
your
doctor
or
pharmacist.
All
medicines
have
risks
and
benefits.
Your
doctor
has
weighed the risks of you taking
Furosemide
AN
against
the
benefits it is expected to have for
you.
IF
YOU
HAVE
ANY
CONCERNS
ABOUT
TAKING
THIS
MEDICINE,
ASK
YOUR
DOCTOR
OR
PHARMACIST.
KEEP
THIS
LEAFLET
WITH
THE
MEDICINE.
You may need to read it again.
WHAT FUROSEMIDE AN
IS USED FOR
Furosemide AN is a water tablet
(or
diuretic).
It
may
be
taken
alone,
or
together
with
other
medicines.
One of its uses is to help reduce
the amount of water in the body
for people who have:

swelling of the ankles, feet
and legs, which doctors call
oedema

swelling of the stomach area
due to liver disease.
Furosemide AN also helps lower
high
blood
pressure,
which
doctors call hypertension.
Everyone
has
blood
pressure.
This pressure helps circulate the
blood
around
your
body.
Your
blood pressure may be different
at
different
times
of
the
day,
depending
on
how
busy
or
worried
you
are.
You
have
hypertension
(high
blood
pressure)
when
your
blood
pressure
stays
higher
than
is
needed,
even
when
you
are
calm and relaxed.
There are usually no symptoms
of hypertension. The only way of
knowing
that
you
have
hypertension
is
to
have
your
blood
pressure
checked
on
a
regular
basis.
If
high
blood
pressure
is
not
treated
it
can
lead to serious health problems.
You may feel fine and have no
symptoms,
but
eventually
hypertension can cause stroke,
heart disease and kidney failure.
Furosemide AN helps to lower
your blood pressure.
Furosemide
AN
works
by
making your kidneys pass more
water
and
salt.
This
helps
reduce high blood pressure and
some forms of swelling.
Your
doctor
may
prescribe
Furosemide
AN
for
anot

Preparatomtale

_Furosemide AN tablets Product Information _
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_ Amneal Pharma Australia Pty Ltd _
Furosemide AN PI v3.0
Page 1
FUROSEMIDE AN
PRODUCT INFORMATION
NAME OF THE MEDICINE
The name of the medicine is furosemide (frusemide).
Chemical name: 4-chloro-2-(furan-2-ylmethylamino)- 5-sulfamoylbenzoic
acid
Molecular Formula: C
12
H
11
ClN
2
O
5
S
Molecular Weight: 330.7
CAS Registry Number: _[54-31-9]_
DESCRIPTION
_ _
Furosemide
is
an
anthranilic
acid
derivative.
Chemical
name:
4-chloro-N-furfuryl-5-
sulfamoylanthranilic acid. Furosemide is a white to off-white
odourless crystalline powder. It
is practically insoluble in water, sparingly soluble in alcohol,
freely soluble in dilute alkali
solutions and insoluble in dilute acids.
_ _
_Inactive_.
Furosemide
AN
20mg,
Furosemide
AN
40mg
tablets:
lactose
monohydrate,
magnesium stearate, maize starch, pregelatinised maize starch, sodium
starch glycollate type
A.
PHARMACOLOGY
Furosemide is a potent diuretic. It inhibits sodium and chloride
absorption in the ascending
limb of the loop of Henle and in both the proximal and the distal
tubule. The high degree of
efficacy is due to this unique site of action. The action on the
distal tubule is independent of
any inhibitory effect on carbonic anhydrase or aldosterone.
Furosemide may promote diuresis in cases which have previously proved
resistant to other
diuretics.
Furosemide has no significant pharmacological effects other than on
renal function.
_Furosemide AN tablets Product Information _
_ _
_ Amneal Pharma Australia Pty Ltd _
Furosemide AN PI v3.0
Page 2
PHARMACOKINETICS
_ABSORPTION_. Furosemide is rapidly absorbed from the gastrointestinal
tract. Absorption rates
have been reported to be from 60 to 69% in healthy subjects and from
43 to 46% in patients
with end stage renal failure.
The onset of diuresis following oral administration is within 1 hour.
The peak effect occurs
within the first or second hour. The duration of diuretic effect is 6
to 8 hours. In fasted normal
men, the mean bioavailability of furosemide from furosemide t