EPHEDRINE SULFATE injection

Land: USA

Språk: engelsk

Kilde: NLM (National Library of Medicine)

Aktiv ingrediens:

Ephedrine Sulfate (UNII: U6X61U5ZEG) (Ephedrine - UNII:GN83C131XS)

Tilgjengelig fra:

Akorn

INN (International Name):

Ephedrine Sulfate

Sammensetning:

Ephedrine Sulfate 50 mg in 1 mL

Administreringsrute:

INTRAMUSCULAR

Resept typen:

PRESCRIPTION DRUG

Indikasjoner:

Ephedrine Sulfate Injection, USP is indicated in the treatment of allergic disorders, such as bronchial asthma The drug has long been used as a pressor agent, particularly during spinal anesthesia when hypotension frequently occurs. In Stokes-Adams syndrome with complete heart block, ephedrine has a value similar to that of epinephrine. It is indicated as a central nervous system stimulant in narcolepsy and depressive states. It is also used in myasthenia gravis. Allergic reactions to ephedrine sulfate are rare. The hypersensitivity, if known, is a specific contraindication. Patients hypersensitive to other sympathomimetics may also be hypersensitive to ephedrine sulfate. Prolonged abuse of Ephedrine Sulfate Injection, USP can lead to symptoms of paranoid schizophrenia. When this occurs, patients exhibit such physical signs as tachycardia, poor nutrition and hygiene, fever, cold sweat and dilated pupils. Some measure of tolerance may develop with prolonged or excessive use but addiction does not occur. Tempor

Produkt oppsummering:

Ephedrine Sulfate Injection USP, 50 mg/mL 1 mL ampules in packs of 10, NDC 17478-515-00 STORAGE: Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Protect from light. Akorn Manufactured by: Akorn, Inc. Lake Forest, IL 60045 ES00N Rev. 03/10

Autorisasjon status:

unapproved drug other

Preparatomtale

EPHEDRINE SULFATE- EPHEDRINE SULFATE INJECTION
AKORN
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this_
_labeling has not been approved by FDA. For further information about
unapproved_
_drugs, click here._
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EPHEDRINE SULFATE
INJECTION USP, 50 MG/ML
For IM, IV or SC Use
RX ONLY
DESCRIPTION
Ephedrine Sulfate Injection, USP is a sterile solution of 50 mg
ephedrine sulfate in Water
for Injection.
Ephedrine occurs as fine, white, odorless crystals or powder and
darkens on exposure
to light. It is freely soluble in water and sparingly soluble in
alcohol.
The chemical name of ephedrine sulfate is (C
H
NO) •H SO benzenemethanol α-[l -
(methylamino) ethyl] - sufate (2:1) (salt). Its molecular weight is
428.54. The structural
formula is:
CLINICAL PHARMACOLOGY
Ephedrine sulfate is a potent sympathomimetic that stimulates both α
and β receptors
and has clinical uses related to both actions. Its peripheral actions,
which it owes in part
to the release of norepinephrine, simulate responses that are obtained
when adrenergic
nerves are stimulated. These include an increase in blood pressure,
stimulation of heart
muscle, constriction of arterioles, relaxation of the smooth muscle of
the bronchi and
gastrointestinal tract, and dilation of the pupils. In the bladder,
relaxation of the detrusor
muscle is not prominent, but the tone of the trigone and vesicle
sphincter is increased.
Ephedrine sulfate also has a potent effect on the CNS. It stimulates
the cerebral cortex
and subcortical centers, which accounts for its use in narcolepsy.
The cardiovascular responses reported in man include moderate
tachycardia,
unchanged or augmented stroke volume, enhanced cardiac output,
variable alterations
in peripheral resistance and usually a rise in blood pressure. The
action of ephedrine is
more prominent on the heart than on the blood vessels. Ephedrine
sulfate increases the
flow of coronary, cerebral and muscle blood.
In patients with myasthenia gravis, administration of Ephedrine
Sulfate Inje