AURO-LISINOPRIL 5 lisinopril (as dihydrate) 5 mg tablet blister pack

Land: Australia

Språk: engelsk

Kilde: Department of Health (Therapeutic Goods Administration)

Aktiv ingrediens:

lisinopril dihydrate

Tilgjengelig fra:

Fair-Med Healthcare Australia Pty Ltd

INN (International Name):

Lisinopril dihydrate

Autorisasjon status:

Registered

Informasjon til brukeren

AURO-LISINOPRIL
CONSUMER MEDICINE INFORMATION
Version 2.5
_ _
Page 1 of 5
AURO-LISINOPRIL 5, 10 & 20
Lisinopril
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS
LEAFLET
This leaflet answers some common
questions
about
AURO-
LISINOPRIL. It does not contain all
the available information.
It does not take the place of talking
to your doctor or pharmacist.
All
medicines
have
risks
and
benefits. Your doctor has weighed
the
risks
of
you
taking
AURO-
LISINOPRIL
against
the
benefits
they expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING
THIS
MEDICINE,
ASK
YOUR
DOCTOR OR PHARMACIST.
KEEP
THIS
LEAFLET
WITH
THE
MEDICINE
. You may need to read it
again.
WHAT
AURO-LISINOPRIL IS
USED FOR
AURO-LISINOPRIL
lowers
high
blood pressure, called hypertension.
It is also used to treat heart failure
and patients who have just had a
heart attack. Lisinopril belongs to a
group
of
medicines
called
ACE
inhibitors.
HYPERTENSION:
Everyone has blood pressure. This
pressure
helps
get
your
blood
all
around your body.
Your
blood
pressure
may
be
different
at
different
times
of
the
day,
depending
on
how
busy
or
worried
you
are.
You
have
hypertension (high blood pressure)
when
your
blood
pressure
stays
higher than is needed, even when
you are calm and relaxed.
There are usually no symptoms of
hypertension.
The
only
way
of
knowing that you have hypertension
is
to
have
your
blood
pressure
checked on a regular basis. If high
blood pressure is not treated it can
lead to serious health problems. You
may
feel
fine
and
have
no
symptoms,
but
eventually
hypertension can cause stroke, heart
disease and kidney failure.
AURO-LISINOPRIL helps to lower
your blood pressure.
HEART FAILURE:
Heart failure means that the heart
muscle cannot pump blood strongly
enough
to
supply
all
the
blood
needed throughout the body. Heart
failure is not the same as heart attack
and
does
not
mean
that
the
heart
stops working.
Heart failure may start off with no
symptoms,
but
as
the
condition
progresses, patients may feel short of
breath or may get tired easily after
lig

Preparatomtale

Product Information:
AURO-LISINOPRIL 5, 10 and 20 (lisinopril 5mg, 10 mg and 20 mg tablets)
Ver 3.4
Page 1 of 19
PRODUCT INFORMATION
AURO-LISINOPRIL 5 (5 MG LISINOPRIL (AS DIHYDRATE) TABLETS)
AURO-LISINOPRIL 10 (10 MG LISINOPRIL (AS DIHYDRATE) TABLETS)
AURO-LISINOPRIL 20 (20 MG LISINOPRIL (AS DIHYDRATE) TABLETS)
NAME OF THE MEDICINE
The name of the medicine is Lisinopril as lisinopril dihydrate.
CHEMICAL NAME:
(
_S_
)-1-[
_N_
2
-(1-carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate
MOLECULAR FORMULA:
C
21
H
31
N
3
O
5
·
2H
2
O.
MOLECULAR WEIGHT:
441.53
CAS REGISTRY NUMBER:
_83915-83-7_
DESCRIPTION
Lisinopril dihydrate is white to off-white crystalline powder that is
soluble in water, sparingly
soluble in methanol and practically insoluble in ethanol. Lisinopril
dihydrate is a synthetic peptide
that is an oral, long acting angiotension converting enzyme inhibitor.
It is a lysine analogue of
enalaprilat (active metabolite of enalapril).
AURO-LISINOPRIL is available as tablets containing 5 mg, 10 mg & 20 mg
lisinopril as dihydrate.
AURO-LISINOPRIL tablets contain following inactive ingredients:
Calcium hydrogen phosphate
anhydrous, mannitol, pregelatinised maize starch, magnesium stearate,
iron oxide red CI77491
(AURO-LISINOPRIL 5 only) & iron oxide yellow CI77492 (AURO-LISINOPRIL
10 and 20).
PHARMACOLOGY
_MECHANISM OF ACTION _
Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the
angiotensin converting enzyme (ACE)
that catalyses the conversion of Angiotensin I to the vasoconstrictor
substance, Angiotensin II.
Angiotensin II also stimulates aldosterone secretion by the adrenal
cortex. Inhibition of ACE
results in decreased concentrations of plasma angiotensin II which
results in decreased vasopressor
activity and decreased aldosterone secretion. The latter decrease may
result in a small increase of
serum potassium.
In hypertensive patients with normal renal function treated with
lisinopril alone for up to 24 weeks,
the mean increase in serum potassium was approximately 0.1 mmol/L;
however, approximatel