ACTOS TABLET 30 mg

Land: Singapore

Språk: engelsk

Kilde: HSA (Health Sciences Authority)

Aktiv ingrediens:

PIOGLITAZONE

Tilgjengelig fra:

CELLTRION HEALTHCARE SINGAPORE PRIVATE LIMITED

ATC-kode:

A10BG03

Dosering :

30 mg

Legemiddelform:

TABLET

Sammensetning:

PIOGLITAZONE 30 mg

Administreringsrute:

ORAL

Resept typen:

Prescription Only

Produsert av:

TAKEDA PHARMACEUTICAL COMPANY LIMITED, HIKARI PLANT

Autorisasjon status:

ACTIVE

Autorisasjon dato:

2003-10-10

Informasjon til brukeren

PACKAGE LEAFLET: INFORMATION FOR THE USER
ACTOS
 15 MG TABLETS
ACTOS
 30 MG TABLETS
Pioglitazone
READ ALL OF THIS LEAFLET CAREFULLY BEFORE YOU START TAKING THIS
MEDICINE.
-
Keep this leaflet. You may need to read it again.
-
If you have any further questions, ask your doctor or pharmacist.
-
This medicine has been prescribed for you. Do not pass it on to
others. It may harm
them, even if their symptoms are the same as yours.
-
If any of the side effects gets serious, or if you notice any side
effects not listed in this
leaflet, please tell your doctor or pharmacist.
IN THIS LEAFLET:
1. What
actos

is and what it is used for
2. Before you take
actos

3. How to take
actos

4. Possible side effects
5. How to store
actos

6. Further information
1. WHAT ACTOS IS AND WHAT IT IS USED FOR
actos

contains pioglitazone. It is an anti-diabetic medicine used to treat
type 2 (non-insulin
dependent) diabetes mellitus. This is the diabetes that usually
develops in adulthood.
actos

helps control the level of sugar in your blood when you have type 2
diabetes by helping
your body make better use of the insulin it produces.
actos

may be used on its own or in combination with metformin and / or a
sulphonylurea
which are also oral anti-diabetic medicines.
2. BEFORE YOU TAKE
ACTOS

DO NOT TAKE
actos

-
if you are hypersensitive (allergic) to pioglitazone or any of the
other ingredients of
actos

.
-
if you have heart failure or have had heart failure in the past.
-
if you have liver disease.
-
if you have or have ever had bladder cancer.
-
if you have blood in your urine that your doctor has not checked.
-
if you have type 1 diabetes – this needs different treatment.
-
if you have acute or chronic metabolic acidosis (a compilation of
diabetes causing rapid
weight loss, nausea or vomiting).
TAKE SPECIAL CARE WITH
actos

Tell your doctor before you start to take this medicine
-
if you retain water (fluid retention) or have heart failures problems
in particular if you
are over 75 years old.
-
if

Preparatomtale

1
ACTOS

(PIOGLITAZONE HYDROCHLORIDE TABLETS)
actos

is an oral antidiabetic agent that acts primarily by decreasing
insulin resistance.
actos

is used in the management of type 2 diabetes mellitus (also known as
non-insulin-
dependent diabetes mellitus [NIDDM] or adult-onset diabetes).
Pharmacological studies
indicate that
actos

improves sensitivity to insulin in muscle and adipose tissue and
inhibits
hepatic gluconeogenesis.
actos

improves glycemic control while reducing circulating insulin
levels.
Pioglitazone
[(+)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-]
thiazolidinedione
monohydrochloride belongs to a different chemical class and has a
different pharmacological
action than the sulfonylureas, metformin, or the
α
-glucosidase inhibitors. The molecule
contains one asymmetric carbon, and the compound is synthesized and
used as the racemic
mixture. The two enantiomers of pioglitazone interconvert
in vivo
. No differences were found
in the pharmacologic activity between the two enantiomers. The
structural formula is as
shown:
Pioglitazone hydrochloride is an odorless white crystalline powder
that has a molecular
formula of C
19
H
20
N
2
O
3
S·HCl and a molecular weight of 392.90 daltons. It is soluble in N,N-
dimethylformamide, slightly soluble in anhydrous ethanol, very
slightly soluble in acetone and
acetonitrile, practically insoluble in water, and insoluble in ether.
CHEMICAL NAME
(+)-5-[p-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione
hydrochloride
COMPOSITION
actos

15 : Each tablet contains 15 mg of pioglitazone
actos

30 : Each tablet contains 30 mg of pioglitazone
DESCRIPTION
actos

15 : White to yellowish white tablet, quadrisect on one side and
bisect on the other.
actos

30 : White to yellowish white tablet.
CLINICAL PHARMACOLOGY
MECHANISM OF ACTION
actos

is a thiazolidinedione antidiabetic agent that depends on the presence
of insulin for its
mechanism of action.
actos

decreases insulin resistance in the periphery and in the liver
res