Selectan 300 mgml solution for injection for cattle and swine.

Country: Malasja

Lingwa: Ingliż

Sors: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredjent attiv:

FLORFENICOL

Disponibbli minn:

Hipra Malaysia Sdn Bhd

INN (Isem Internazzjonali):

FLORFENICOL

Unitajiet fil-pakkett:

100.00 mcg/mL; 250.00 mcg/mL; 50 ml; 100 ml

Manifatturat minn:

Laboratorios Hipra, S.A.

Karatteristiċi tal-prodott

705096-03.1
02-19
SELECTAN
300 mg/ml, solution for injection for cattle and swine
COMPOSITION PER ML:
Florfenicol
300 mg
Excipient q.s.ad
1 ml
A slightly yellowish and clear solution.
Florfenicol
is
a
systemic
broad
spectrum
antibiotic effective against most Gram-positive
and
Gram-negative
bacteria
isolated
from
domestic animals. Florfenicol acts by inhibiting
protein synthesis at the ribosomal level and is
bacteriostatic.
However,
in
vitro
studies
of
florfenicol
demonstrate
bactericidal
activity
against
_Mannheimia _
_haemolytica, _
_Pasteurella _
_multocida, Actinobacillus pleuropneumoniae,_ and
_Histophilus somni. _
In vitro testing has shown that florfenicol is active against the
bacterial
pathogens most commonly isolated in respiratory diseases in cattle
(including _ Pasteurella multocida, Mannheimia haemolytica,
Histophilus _
_somni_
and
_Arcanobacterium _
_pyogenes_)
and
in
pigs
(including
_Actinobacillus pleuropneumoniae_ and _Pasteurella multocida_).
In cattle, intramuscular administration at the recommended dose of 20
mg/kg maintains efficacious blood levels for 48 hours. Maximum mean
serum concentration (C
max
) of 2.55 μg/ml occurs at 4.7 hours (T
max
) after
dosing. The mean serum concentration 24 hours after dosing was 1.4
μg/ml. The harmonic mean elimination half life was 26.2 hours.
In pigs, after initial intramuscular administration of florfenicol,
maximum
serum concentrations of between 1.9 and 3.1 μg/ml are reached after
2.2 hours and the concentrations deplete with a terminal mean
half-life of
35.5 hours. After a second intramuscular administration, maximum
serum concentrations of between 2.0 and 8.1 μg/ml are reached after
1.7 hours. Florfenicol concentrations achieved in lung tissue reflect
plasma
concentrations,
with
a
lung:
plasma
concentration
ratio
of
approximately 1.
After administration to pigs by intramuscular route, florfenicol is
rapidly
excreted, primarily in urine. The florfenicol is extensively
metabolised.
INDICATIONS:
Diseases caused by florfenicol susceptible bacteria:
Cat