Progout

Pajjiż: Awstralja

Lingwa: Ingliż

Sors: Department of Health (Therapeutic Goods Administration)

Ingredjent attiv:

Allopurinol

Disponibbli minn:

Alphapharm Pty Ltd

Klassi:

Medicine Listed (Export Only)

Fuljett ta 'informazzjoni

PROGOUT

_contains the active ingredient allopurinol_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Progout.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking Progout against
the benefits expected for you or your
child.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT PROGOUT IS USED
FOR
Progout is used in the treatment of:
•
gouty arthritis or gout, a
condition of painful swollen
joints caused by uric acid crystals
•
kidney stones
•
other rare conditions where high
levels of uric acid occur in the
blood, for example Lesch-Nyhan
syndrome.
Progout helps to treat the symptoms
of these conditions but will not cure
them. It will not help treat the pain
that occurs in an acute attack of gout.
Progout belongs to a group of
medicines called anti-uricaemic
agents. These medicines reduce the
amount of uric acid in the body. Most
commonly, high levels of uric acid in
the body are related to gout. Excess
amounts of uric acid in the blood
may lead to the development of
crystals which deposit in the joints,
causing pain, swelling and
tenderness.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY PROGOUT HAS
BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed
Progout for another reason.
Progout is available only with a
doctor's prescription.
There is no evidence that Progout is
addictive.
BEFORE YOU TAKE
PROGOUT
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE PROGOUT IF YOU ARE
ALLERGIC TO MEDICINES CONTAINING
ALLOPURINOL (E.G. ZYLOPRIM) OR ANY
OF THE INGREDIENTS LISTED AT THE END
OF THIS LEAFLET, INCLUDING LACTOSE.
Some of the symptoms of an allergic
reaction may include skin rash,
itching or hives; swelling of the face,
lips or tongue which may cause
difficulty in swallowing or breathin

Karatteristiċi tal-prodott

PROGOUT 
_Allopurinol _

PRODUCT INFORMATION 

NAME OF THE MEDICINE 

The active ingredient of Progout tablets is allopurinol. 

Chemical name: 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one. 

Structural formula: 

Molecular formula: 
C
5
H
4
N
4
O 
  Molecular 
weight: 
136.1 
       CAS 
Registry 
no.: 
315-30-0 

DESCRIPTION

Allopurinol is a white or off-white, almost odourless powder. It is
very slightly soluble in water and 
in alcohol, and is practically insoluble in chloroform and in ether.
It dissolves in dilute solutions of 
alkali hydroxides. 

Each Progout 100 tablet contains 100 mg of allopurinol.  The tablets
also contain the following 
inactive ingredients: lactose, starch - maize, povidone, macrogol
8000, sodium lauryl sulfate, talc - 
purified and magnesium stearate.  The tablets are gluten free. 

Each Progout 300 tablet contains 300 mg of allopurinol.  The tablets
also contain the following 
inactive ingredients: starch - maize, povidone, maltodextrin, sodium
starch glycollate, cellulose  - 
microcrystalline and magnesium stearate. 

PHARMACOLOGY

Allopurinol inhibits xanthine oxidase, the enzyme which catalyses
the conversion of hypoxanthine to 
xanthine, and of xanthine to urate/uric acid. 

Allopurinol decreases urate formation in two ways: 

1.  The inhibition of xanthine oxidase reduces the amount of
hypoxanthine and xanthine converted to 
urate/uric acid. 

2.  This action makes more hypoxanthine and xanthine available
for re-utilisation in the purine 
metabolic cycle, which in turn, by a feedback mechanism, decreases
overall _de novo_ purine 
formation. 

Since allopurinol decreases urate formation, it reduces urate/uric
acid concentrations in both body 
fluids and urine.  In contrast, the uricosuric agents which
increase urate/uric acid excretion via the 
kidney will reduce the urate concentration in body fluids,
but increase urate/uric acid concentrations in 
urine