LIDOCAINE HYDROCHLORIDE injection, solution

Pajjiż: Stati Uniti

Lingwa: Ingliż

Sors: NLM (National Library of Medicine)

Ingredjent attiv:

LIDOCAINE HYDROCHLORIDE (UNII: V13007Z41A) (LIDOCAINE - UNII:98PI200987)

Disponibbli minn:

Hospira, Inc.

Rotta amministrattiva:

INFILTRATION

Tip ta 'preskrizzjoni:

PRESCRIPTION DRUG

Indikazzjonijiet terapewtiċi:

Lidocaine HCl injection is indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these techniques as described in standard textbooks are observed. Lidocaine HCl is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type.

Sommarju tal-prodott:

2% Lidocaine Hydrochloride Injection, USP: NDC 0409-2066-05 Carton of 10 Single-dose Vials 2% 100 mg/5 mL (20 mg/mL) Discard unused portion after initial use. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.]

L-istatus ta 'awtorizzazzjoni:

Abbreviated New Drug Application

Karatteristiċi tal-prodott

LIDOCAINE HYDROCHLORIDE- LIDOCAINE HYDROCHLORIDE INJECTION, SOLUTION
HOSPIRA, INC.
----------
2% LIDOCAINE HYDROCHLORIDE
INJECTION, USP
FOR INFILTRATION AND NERVE BLOCK
Rx only
DESCRIPTION
Lidocaine hydrochloride has the chemical name of acetamide,
2-(diethylamino)-N-(2,6-
dimethylphenyl)-,monohydrochloride and has the molecular weight of
270.8. Lidocaine
HCl (C
H
N O • HCl) has the following structural formula:
Each single-dose vial contains Lidocaine Hydrochloride Injection, USP,
which is a sterile
nonpyrogenic aqueous solution intended for parenteral administration
as a local
anesthetic agent. See INDICATIONS AND USAGE for special uses.
Each mL contains 20 mg lidocaine hydrochloride and 6 mg sodium
chloride, in Water for
Injection. Sodium hydroxide and/or hydrochloric acid may be used to
adjust pH between
5.0 and 7.0.
CLINICAL PHARMACOLOGY
MECHANISM OF ACTION
Lidocaine HCl stabilizes the neuronal membrane by inhibiting the ionic
fluxes required for
the initiation and conduction of impulses thereby effecting local
anesthetic action.
HEMODYNAMICS
Excessive blood levels may cause changes in cardiac output, total
peripheral resistance,
and mean arterial pressure. With central neural blockade these changes
may be
14
22
2
attributable to block of autonomic fibers, a direct depressant effect
of the local
anesthetic agent on various components of the cardiovascular system,
and/or the beta-
adrenergic receptor stimulating action of epinephrine when present.
The net effect is
normally a modest hypotension when the recommended dosages are not
exceeded.
PHARMACOKINETICS AND METABOLISM
Information derived from diverse formulations, concentrations and
usages reveals that
lidocaine HCl is completely absorbed following parenteral
administration, its rate of
absorption depending, for example, upon various factors such as the
site of
administration and the presence or absence of a vasoconstrictor agent.
Except for
intravascular administration, the highest blood levels are obtained
following intercostal
nerve block and the low