LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE- lidocaine hydrochloride anhydrous and epinephrine injection, solution

Country: Stati Uniti

Lingwa: Ingliż

Sors: NLM (National Library of Medicine)

Ingredjent attiv:

LIDOCAINE HYDROCHLORIDE (UNII: V13007Z41A) (LIDOCAINE - UNII:98PI200987), EPINEPHRINE (UNII: YKH834O4BH) (EPINEPHRINE - UNII:YKH834O4BH)

Disponibbli minn:

Cardinal Health 107, LLC

Rotta amministrattiva:

INFILTRATION

Tip ta 'preskrizzjoni:

PRESCRIPTION DRUG

Indikazzjonijiet terapewtiċi:

Lidocaine Hydrochloride and Epinephrine Injection, USP is indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection, by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these techniques as described in standard textbooks are observed. Lidocaine HCl is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type.

Sommarju tal-prodott:

Lidocaine Hydrochloride and Epinephrine Injection, USP is supplied in single-dose and multiple-dose containers as shown below: Lidocaine HCl 1% and Epinephrine 1:100,000 Injection, USP is available overbagged with 5 x 20 mL Multiple-Dose Fliptop Vials per bag, NDC 55154-0132-5 Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from light.    Distributed by Hospira, Inc., Lake Forest, IL 60045 USA                                                                              Distributed by: Cardinal Health Dublin, OH 43017 L28636520224 LAB-1298-2.0 Revised: 08/2019

L-istatus ta 'awtorizzazzjoni:

Abbreviated New Drug Application

Karatteristiċi tal-prodott

LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE- LIDOCAINE HYDROCHLORIDE
ANHYDROUS AND EPINEPHRINE INJECTION, SOLUTION
CARDINAL HEALTH 107, LLC
----------
LIDOCAINE HYDROCHLORIDE
AND EPINEPHRINE
INJECTION, USP
For Infiltration and Nerve Block
AMPUL
FLIPTOP VIAL
MULTIPLE-DOSE FLIPTOP VIAL
PROTECT FROM LIGHT.
Rx only
DESCRIPTION
Lidocaine Hydrochloride and Epinephrine Injection, USP is a sterile,
nonpyrogenic
solution of lidocaine hydrochloride and epinephrine in water for
injection for parenteral
administration in various concentrations with characteristics as
follows:
CONCENTRATION
LIDOCAINE HCL
EPINEPHRINE
LIDOCAINE HCL
(ANHYD.)
MG/ML
EPINEPHRINE
MCG/ML
SODIUM
CHLORIDE
MG/ML
0.5%
1:200,000
5
5
8
1%
1:200,000
10
5
7
1.5%
1:200,000
15
5
6.5
2%
1:200,000
20
5
6
1%
1:100,000
10
10
7
2%
1:100,000
20
10
6
Sodium metabisulfite 0.5 mg/mL and citric acid, anhydrous 0.2 mg/mL
added as
stabilizers. The headspace of Lists 1209, 3177, 3178, 3181, 3182 and
3183 are nitrogen
gassed. May contain sodium hydroxide and/or hydrochloric acid to
adjust pH; pH is 4.5
(3.3 to 5.5). See HOW SUPPLIED section for various sizes and
strengths.
Multiple-dose vials contain methylparaben 1 mg/mL added as
preservative.
Single-dose ampuls and vials contain no bacteriostat or antimicrobial
agent. Discard
unused portion.
Lidocaine is a local anesthetic of the amide type.
Lidocaine Hydrochloride, USP is chemically designated
2-(diethyl-amino)-2',6'-
acetoxylidide monohydrochloride monohydrate, a white powder freely
soluble in water. It
has the following structural formula:
Epinephrine, USP is a sympathomimetic (adrenergic) agent designated
chemically as 4-
[1-hydroxy-2 (methylamino) ethyl]-1,2 benzenediol, a white,
microcrystalline powder. It
has the following structural formula:
CLINICAL PHARMACOLOGY
MECHANISM OF ACTION Lidocaine HCl stabilizes the neuronal membrane by
inhibiting the
ionic fluxes required for the initiation and conduction of impulses
thereby effecting local
anesthetic action.
HEMODYNAMICS Excessive blood levels may cause changes in cardia