Irbesartan HCT Sanofi

Pajjiż: Awstralja

Lingwa: Ingliż

Sors: Department of Health (Therapeutic Goods Administration)

Ingredjent attiv:

Hydrochlorothiazide; Irbesartan

Disponibbli minn:

Sanofi-Aventis Australia Pty Ltd

Klassi:

Medicine Registered

Fuljett ta 'informazzjoni

Irbesartan-hct-sanofi-ccdsv8-cmiv2-10may13 
IRBESARTAN HCT SANOFI
®

_irbesartan & hydrochlorothiazide _
CONSUMER MEDICINE INFORMATION (CMI) 

WHAT IS IN THIS LEAFLET 
This leaflet answers some common 
questions about Irbesartan HCT 
Sanofi. It does not contain all the 
available information. It does not 
take the place of talking to your 
doctor or pharmacist. 
All medicines have benefits and 
risks. Your doctor has weighed the 
benefits of you taking this medicine 
against the risks it will have for you. 
IF YOU HAVE ANY CONCERNS ABOUT 
TAKING THIS MEDICINE, ASK YOUR 
DOCTOR OR PHARMACIST. 
KEEP THIS LEAFLET WITH YOUR 
MEDICINE. 
You may need to read it again. 

WHAT IRBESARTAN HCT 
SANOFI IS USED FOR 
Irbesartan HCT Sanofi is used to 
lower high blood pressure, which 
doctors call hypertension. 
Everyone has blood pressure. This 
pressure helps get your blood all 
around your body. Your blood 
pressure may be different at different 
times of the day, depending on how 
busy or worried you are. You have 
hypertension (high blood pressure) 
when your blood pressure stays 
higher than is needed, even when you 
are calm and relaxed. 
There are often no symptoms of high 
blood pressure. The only way of 
knowing that you have high blood 
pressure is to have your blood 
pressure checked on a regular basis. 
If high blood pressure is not treated it 
can lead to serious health problems, 
such as stroke, heart disease and 
kidney failure. 
_HOW IRBESARTAN HCT SANOFI _
_WORKS _
Irbesartan HCT Sanofi contains 
irbesartan and hydrochlorothiazide. 
Both medicines reduce blood 
pressure in different ways. Irbesartan 
belongs to a group of medicines 
known as angiotensin-II receptor 
antagonists. Angiotensin-II is a 
substance produced in the body that 
causes blood vessels to narrow. 
Irbesartan blocks angiotensin-II and 
therefore widens your bloo

Karatteristiċi tal-prodott

PRODUCT INFORMATION  
May-2013 
Irbesartan HCT Sanofi - irbesartan hydrochlorothiazide   
Property of the sanofi-aventis group   
irbesartan-hct-sanofi-ccdsv8-piv2-10may13 
1
PRODUCT INFORMATION 
IRBESARTAN HCT SANOFI
®

NAME OF MEDICINE 
AUSTRALIAN APPROVED NAME 
Irbesartan/Hydrochlorothiazide 
Irbesartan: 2-butyl-3-[(2'-(1_H_-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,3-diazaspiro[4,4]non-1-en-4-
one 
Hydrochlorothiazide:
6-chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7-sulfonamide
1,1-dioxide   
CHEMICAL STRUCTURE 
The chemical structure of irbesartan is:  
The empiric formula is C
25
H
28
N
6
O and the molecular weight, 428.5.   
The CAS registry number for irbesartan is: CAS-138402-11-6. 
The chemical structure of hydrochlorothiazide is: 

The empiric formula is C
7
H
8
ClN
3
O
4
S
2
 and the molecular weight, 297.7.   
N
N
O
(CH
2
)
3
CH
3
N
N
N
N
H
N
N
S
CL
H
H
O
O
S
H
2
N
O
O
PRODUCT INFORMATION  
May-2013 
Irbesartan HCT Sanofi - irbesartan hydrochlorothiazide   
Property of the sanofi-aventis group   
irbesartan-hct-sanofi-ccdsv8-piv2-10may13 
2
The CAS registry number for hydrochlorothiazide is: CAS-58-93-5 
DESCRIPTION 
Irbesartan HCT Sanofi (irbesartan/hydrochlorothiazide) is an
oral antihypertensive agent 
combining a nonpeptide angiotensin II receptor (AT
1
 subtype) antagonist, irbesartan, and a 
thiazide diuretic, hydrochlorothiazide. 
Irbesartan is a white to off-white crystalline powder.  It is a
relatively non-polar compound with a 
partition coefficient (octanol-water) of 10.1 at a pH
of 7.4.  Irbesartan is slightly soluble in alcohol 
and methylene chloride, and practically insoluble in water. 
Hydrochlorothiazide is a white crystalline powder.  It
is slightly soluble in water but freely soluble 
in sodium hydroxide solution. 
Irbesartan HCT Sanofi 150/12.5 tablets contain 150 mg of
irbesartan and 12.5 mg of 
hydrochlorothiazide and are peach to mott