Ezetrol

Pajjiż: Awstralja

Lingwa: Ingliż

Sors: Department of Health (Therapeutic Goods Administration)

Ingredjent attiv:

Ezetimibe

Disponibbli minn:

Merck Sharp & Dohme Australia Pty Ltd

Klassi:

Medicine Registered

Fuljett ta 'informazzjoni

EZETROL
®

(PRONOUNCED EZ-EH-TROL)
_Ezetimibe_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about EZETROL. It does
not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking EZETROL
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT EZETROL IS
USED FOR
EZETROL helps to lower cholesterol
levels. It is used in people whose
cholesterol levels are too high and
when diet alone cannot lower these
levels adequately.
EZETROL may be taken alone or
with other cholesterol-lowering
medicines known as HMG-CoA
reductase inhibitors (or statins), in
addition to diet.
In people who have high levels of
plant sterols in their blood (which
doctors call sitosterolaemia),
EZETROL helps to lower these
levels.
_CHOLESTEROL_
Cholesterol is one of several fatty
substances found in the bloodstream.
Your total cholesterol is made up
mainly of LDL and HDL cholesterol.
LDL cholesterol is often called 'bad'
cholesterol because it can build up in
the walls of your arteries forming
plaque. Eventually this plaque build-
up can lead to a narrowing of the
arteries.
This narrowing can slow or block
blood flow to vital organs such as the
heart and brain. This blocking of
blood flow can result in a heart attack
or stroke.
HDL cholesterol is often called
'good' cholesterol because it helps
keep the bad cholesterol from
building up in the arteries and
protects against heart disease.
_TRIGLYCERIDES_
Triglycerides are another form of fat
in your blood that may increase your
risk for heart disease.
_HOW EZETROL WORKS_
EZETROL reduces elevated total-
cholesterol, LDL (bad) cholesterol
and triglycerides and increases HDL
(good) cholesterol.
EZETROL works by decreasing the
absorption of cholesterol

Karatteristiċi tal-prodott

 
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PRODUCT INFORMATION 

EZETROL
Ò [/au_hum_1410_SPC.html#1]

(EZETIMIBE) 

NAME OF THE MEDICINE  

EZETROL, ezetimibe is described
chemically as 1-(4-fluorophenyl)-3(R)-[3-(4-
fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone.    The CAS 
registry number is 163222-33-1.  The empirical formula is C
24
H
21
F
2
NO
3
.  Its molecular 
weight is 409.4 and its structural formula is: 

DESCRIPTION 

Ezetimibe is a white, crystalline
powder that is freely to very soluble in ethanol, 
methanol, and acetone and practically insoluble in water. 
Ezetimibe has a melting point 
of about 163°C and is stable at ambient temperature.  

Each tablet of EZETROL for oral administration contains 10
mg ezetimibe. 

Each 10
mg tablet contains croscarmellose sodium, lactose, magnesium stearate, 
microcrystalline cellulose, povidone and sodium lauryl sulfate. 

PHARMACOLOGY 
MECHANISM OF ACTION: 

EZETROL (ezetimibe) is in a
class of lipid-modifying compounds that inhibit the 
intestinal absorption of cholesterol and related
plant sterols.  

Ezetimibe has a mechanism of action
that differs from other classes of cholesterol 
reducing compounds (eg statins, bile acid
sequestrants [resins], fibric acid derivatives, 
and plant sterols.) 

N
O H
F
F
S
S
R
O
O H

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The molecular target of ezetimibe is the
sterol transporter, Niemann-Pick C1-Like  1 
(NPC1L1), which is responsible for the
intestinal uptake of cholesterol and phytosterols.  
Ezetimibe therefore inhibits the absorption
of cholesterol, leading to a decrease in the 
delivery of intestinal cholesterol to the liver.  This causes a
reduction of