DUOTRIC FILM COATED TABLET 200MG

Pajjiż: Malasja

Lingwa: Ingliż

Sors: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredjent attiv:

CIMETIDINE

Disponibbli minn:

MILRIN PHARMACEUTICAL CO. (M) SDN BHD

INN (Isem Internazzjonali):

CIMETIDINE

Unitajiet fil-pakkett:

1000Tablet Tablets; 1000 Tablet Tablets

Manifatturat minn:

ASIAN PHARM LTD PART

Fuljett ta 'informazzjoni

DUOTRIC FILM COATED TABLET
Cimetidine (200mg, 400mg)
1
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
WHAT IS IN THIS LEAFLET
1.
What Duotric is used for
2.
How Duotric works
3.
Before you use Duotric
4.
How to use Duotric
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Duotric
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT DUOTRIC IS USED FOR
Duotric is used for
•
Treatment of ulcer in upper part
of the intestine (duodenal ulcer).
•
Prevention
of
duodenal
ulcer
and its recurrence.
•
Treatment
of
acid
reflux
in
which the acidic content of the
stomach flows back up into your
food pipe.
•
Treatment of high gastric acid
production
conditions
such
as
Zollinger-Ellison Syndrome.
HOW DUOTRIC WORKS
Duotric contain cimetine. Cimetidine
belongs
to
a
group
of
medicine
called H2-receptor antagonist which
act
to
suppress
the
secretion
of
gastric acid.
BEFORE YOU USE DUOTRIC
-
_When you must not use it _
Do
not
take
Duotric
if
you
are
allergic to cimetidine or any of the
ingredients in this medicine.
_ _
-
_Before you start use it _
Tell your doctor if:
•
You
have
history
of
stomach,
small intestine or food pipe ulcer.
•
You
are
pregnant
or
breastfeeding
as
cimetidine
is
secreted in human milk.
•
You have kidney or liver disease
•
You
have
gradual
decrease
in
brain function
•
You have stomach cancer
-
_Taking other medicines _
Tell your doctor if you are taking
•
Warfarin-type
anticoagulant
(used to treat blood clots)
•
Phenytoin
(used
to
treat
seizures).
•
Propranolol, nifedipine (used to
treat high blood pressure).
•
Chlordiazepoxide,
diazepam
(used to treat anxiety and alcohol
withdrawal).
•
Certain tricyclic antidepressants.
•
Lidocaine (used to reduce pain or
discomfort
during
medical
procedures).
•
Theophylline (used to treat lung
disease).
•
Metronidazole (antibiotic).
•
Any other medicines, including
any
that
you
buy
without
a
prescription
from
a
pharmacy,
supermarket or health food shop.
HOW TO USE DUOTRIC
-

Karatteristiċi tal-prodott

PACKAGE INSERT
PACKAGE INSERT
DUOTRIC FILM COATED TABLET 200MG
DUOTRIC FILM COATED TABLET 400MG
1.
NAME(S) AND STRENGTH OF ACTIVE INGREDIENT(S):
DUOTRIC FILM COATED TABLET 200MG
: Each tablet contains Cimetidine 200mg
DUOTRIC FILM COATED TABLET 400MG
: Each tablet contains Cimetidine 400mg
2.
DOSAGE FORM:
Film coated tablet.
3.
DESCRIPTION:
DUOTRIC FILM COATED TABLET 200MG
Light-green, circular, biconvex,film-coated tablet with a central
division line on one side.
DUOTRIC FILM COATED TABLET 400MG
Light green, oblong, biconvex, film-coated tablets with “ASP-400”
imprinted on one side.
4.
PHARMACODYNAMICS:
‘Duotric’ is a reversible competitive antagonist of the action of
histamine that are extended on H
2
receptors. It markedly reduces
the volume and concentration of gastric acid secreted in the fasting
state and after stimulation by food, histamine, pentagastrin,
insulin, 2 deoxyglucose, bethanecol and caffeine. By suppressing the
secretion of gastric acid it creates a local environment that
favours the spontaneous healing of the ulcer. It also make life more
comfortable for the duodenal ulcer patient by relieving him/her
of the nocturnal and sleep-disturbing pains that otherwise occur when
hydrochloric acid secreted in response to a lack of food in
the stomach, passes into the ulcerated duodenum. It is certainly a
more effective curative agent than carbonoxolone and would
become a most useful drug for the treatment of peptic ulcer.
Controlled and uncontrolled studies in hospitalised and outpatients
reveal that when cimetidine was given in a dosage of 0.82g
daily for six weeks, 70-90% of patients with duodenal ulcer and
70-100% of patients with gastric ulcer experienced healing: in
comparison, beneficial effects were observed in 30-70% of the
ambulatory control patients and in almost 80% of the hospitalised
control patients with duodenal and gastric ulcer. In most instances,
these results were confirmed by direct endoscopic
visualisation.
5.
PHARMACOKINETICS:
‘Duotric’ is absorbed mostly from the small