Crestor

Pajjiż: Awstralja

Lingwa: Ingliż

Sors: Department of Health (Therapeutic Goods Administration)

Ingredjent attiv:

Rosuvastatin calcium

Disponibbli minn:

AstraZeneca Pty Ltd

Klassi:

Medicine Registered

Fuljett ta 'informazzjoni

CRESTOR
®

_Rosuvastatin calcium_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some of the
common questions people ask about
CRESTOR. It does not contain all
the information that is known about
CRESTOR.
It does not take the place of talking to
your doctor and pharmacist.
All medicines have risks and
benefits. Your doctor will have
weighed the risks of you taking
CRESTOR against the benefits they
expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT CRESTOR IS FOR
CRESTOR is used to lower high
cholesterol levels.
Even though you may have normal
cholesterol, CRESTOR can also be
used to reduce the risk of you having
a stroke or heart attack if you are a
man 50 or more years old or a
women 60 or more years old and
have at least 2 risk factors for having
a heart attack or stroke, such as high
blood pressure, low levels of good
cholesterol (HDL), smoking or a
family history of premature coronary
heart disease. Your doctor may also
do a blood test to measure a
substance called C Reactive Protein
to help decide if you should be given
CRESTOR for this use.
_CHOLESTEROL AND_
_TRIGLYCERIDES_
Everyone has cholesterol and
triglycerides in their blood. They are
fatty substances needed by the body
for many things.
Triglycerides are an energy source
for the body. Cholesterol is used for
such things as building cells, making
bile acids (which help to digest
foods) and making some hormones.
There are different types of
cholesterol. Too much of the "bad"
cholesterol (LDL) can block the
blood vessels that supply your heart
and brain with blood, and can cause
heart attack, angina and stroke. The
"good" cholesterol (HDL) helps to
remove the bad cholesterol from the
blood vessels. High levels of
triglycerides can be associated with a
low level of "good" cholesterol and
may increase the risk of heart
disease.
_HOW CRESTOR WORKS_
CRESTOR belongs to a group of
med

Karatteristiċi tal-prodott

CRESTOR
®
 Product Information 
CV.000-332-812.13.0 
1(27) 
CRESTOR
®

rosuvastatin calcium 
PRODUCT INFORMATION 

NAME OF THE MEDICINE 
The active ingredient in CRESTOR
®
 is rosuvastatin, as rosuvastatin calcium.  
The chemical name is bis [(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-
[methyl(methylsulfonyl) amino]pyrimidin-5-yl]
(3R, 5S)-3,5-dihydroxyhept-6-
enoic acid] calcium salt.   
CRESTOR, rosuvastatin calcium, is
a HMG-CoA reductase inhibitor for the 
treatment of dyslipidaemia.   
The chemical structure of rosuvastatin calcium is: 
N
N
F
N
SO
2
Me
O
OH
OH
O
2
Ca
2+

CAS Number:  
147098-20-2 
Molecular formula:  (C
22
H
27
FN
3
O
6
S)
2
Ca 
Molecular weight: 
1001.14 
DESCRIPTION 
Rosuvastatin calcium is an amorphous solid, which is
slightly soluble in water 
(7.8 mg/mL at 37°C) and has
a pKa of 4.6.  Rosuvastatin calcium is the 
(3_R_,5_S_,6_E_) enantiomer.   
CRESTOR film-coated tablets contain 5 mg, 10 mg, 20 mg and 40 mg of 
rosuvastatin (as calcium).
 The tablets also contain the following inactive 
ingredients: crospovidone, lactose, microcrystalline cellulose, calcium 
phosphate, magnesium stearate, glycerol
triacetate, hypromellose and titanium 
dioxide.  The 5 mg tablets also contain iron oxide yellow CI77492 whereas
the 
10 mg, 20 mg and 40 mg tablets contain iron oxide red CI77491.   
CRESTOR
®
 Product Information 
CV.000-332-812.13.0 
2(27) 
PHARMACOLOGY 
Rosuvastatin is a fully synthetic
competitive inhibitor of HMG-CoA reductase, 
the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl
coenzyme A 
to mevalonate, a precursor of cholesterol.  Triglycerides (TG)
and cholesterol in 
the liver are incorporated, with apolipoprotein B (ApoB),
into very low density 
lipoprotein (VLDL) and released into the plasma for
delivery to peripheral 
tissues.  VLDL particles
are TG-rich.